Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3165146..3165806 Replicon chromosome
Accession NZ_CP091997
Organism Salmonella enterica subsp. enterica serovar Kentucky strain N20-2289

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag MA641_RS15415 Protein ID WP_000244756.1
Coordinates 3165146..3165559 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag MA641_RS15420 Protein ID WP_000351186.1
Coordinates 3165540..3165806 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MA641_RS15395 (3161087) 3161087..3162820 - 1734 WP_023223830.1 single-stranded-DNA-specific exonuclease RecJ -
MA641_RS15400 (3162826) 3162826..3163539 - 714 WP_023223829.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MA641_RS15405 (3163563) 3163563..3164459 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
MA641_RS15410 (3164572) 3164572..3165093 + 522 WP_001055885.1 flavodoxin FldB -
MA641_RS15415 (3165146) 3165146..3165559 - 414 WP_000244756.1 protein YgfX Toxin
MA641_RS15420 (3165540) 3165540..3165806 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
MA641_RS15425 (3166056) 3166056..3167036 + 981 WP_000874178.1 tRNA-modifying protein YgfZ -
MA641_RS15430 (3167152) 3167152..3167811 - 660 WP_000250289.1 hemolysin III family protein -
MA641_RS15435 (3167975) 3167975..3168286 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
MA641_RS15440 (3168444) 3168444..3169877 + 1434 WP_001230143.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T235378 WP_000244756.1 NZ_CP091997:c3165559-3165146 [Salmonella enterica subsp. enterica serovar Kentucky]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T235378 NZ_LR134244:820331-820693 [Staphylococcus warneri]
ATGATTAGAAGAGGAGATGTTTATCTAGCAGATTTATCACCTGTTCAAGGGTCAGAACAAGGGGGAGTAAGACCCGTCGT
CATTATCCAAAATGACACAGGTAATAAATATAGTCCTACTGTTATTGTTGCCGCAATCACTGGAAGGATTAATAAAGCTA
AGATACCTACACATGTTGAAATTGAAAAGAAAAAGTACAAACTTGATAAGGACTCAGTTATTTTATTAGAACAAATTCGT
ACTTTAGATAAAAATCGTTTAAAAGAAAAACTCACATATTTGTCTGATAACAAAATGAAAGAAGTAGATTACGCCCTAGA
CATTAGTCTAGGTTTACATAATTTCAATCATTCTAAGACATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT235378 WP_000351186.1 NZ_CP091997:c3165806-3165540 [Salmonella enterica subsp. enterica serovar Kentucky]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT235378 NZ_LR134244:820164-820334 [Staphylococcus warneri]
ATGTTATCTTTTAATCAAAATAGAAGTTACAGTTTAGAGCAATCTTTAAAAGAAGGTTATGCACAAATGGCTGATTTAAA
TCTCTCCCTAGCAACCGAAGCTTTTCCTATTGAATGTGAAGCGTGCGATTGCAATGAAACATATTTAACTTCTAACGCTA
AGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References