Detailed information of TA system TA235377

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 2956240..2957054
• Replicon: chromosome
• Accession: NZ_CP091997
• Organism: Salmonella enterica subsp. enterica serovar Kentucky strain N20-2289

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: A0A3G3DUX8
• Locus tag: MA641_RS14370
• Protein ID: WP_000971653.1
• Coordinates: 2956527..2957054 (+)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: M7S6I2
• Locus tag: MA641_RS14365
• Protein ID: WP_000855694.1
• Coordinates: 2956240..2956530 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MA641_RS14335 (2952165)	2952165..2952815	-	651	WP_072203970.1	type III secretion system transcriptional activator InvF	-
MA641_RS14340 (2953273)	2953273..2953716	+	444	WP_023225039.1	SPI-1 type III secretion system invasion lipoprotein InvH	-
MA641_RS14345 (2954148)	2954148..2954597	+	450	WP_023225038.1	hypothetical protein	-
MA641_RS14350 (2954582)	2954582..2954929	+	348	WP_001555786.1	DUF1493 family protein	-
MA641_RS14355 (2955202)	2955202..2955528	-	327	WP_000393295.1	hypothetical protein	-
MA641_RS14360 (2955769)	2955769..2955969	+	201	Protein_2810	transposase	-
MA641_RS14365 (2956240)	2956240..2956530	+	291	WP_000855694.1	DUF1778 domain-containing protein	Antitoxin
MA641_RS14370 (2956527)	2956527..2957054	+	528	WP_000971653.1	GNAT family N-acetyltransferase	Toxin
MA641_RS14375 (2957127)	2957127..2957329	-	203	Protein_2813	IS5/IS1182 family transposase	-
MA641_RS14380 (2957679)	2957679..2958335	+	657	WP_023225036.1	protein-serine/threonine phosphatase	-
MA641_RS14385 (2958507)	2958507..2959001	-	495	WP_000424946.1	hypothetical protein	-
MA641_RS14390 (2959028)	2959028..2959696	-	669	WP_000445914.1	hypothetical protein	-
MA641_RS14395 (2959853)	2959853..2960071	-	219	Protein_2817	hypothetical protein	-
MA641_RS14400 (2960282)	2960282..2960680	-	399	Protein_2818	cytoplasmic protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	2955769..2957303	1534

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (1-95)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 19043.87 Da
• Isoelectric Point: 9.7032

>T235377 WP_000971653.1 NZ_CP091997:2956527-2957054 [Salmonella enterica subsp. enterica serovar Kentucky]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRHDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Nucleotide

• Length: 528 bp

>T235377 NZ_LR134244:809345-809551 [Staphylococcus warneri]
GTGCAACAAAAAATTGTATATACTGCTGGAATAGAAACACAAGAACAATCTGAAGCTATAAAAAATCTTTTAACTGAAAT
GATAGGTGTATATCAAGTTGATATTGATATCAATTCTGGAAACATAACAATTGAATTTGAGACACCTGCGAATTTAAATA
GTATTGAAAAAGAAATTTATGATGCTGGATATAAAGTGCTCTATTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10664.50 Da
• Isoelectric Point: 6.3133

>AT235377 WP_000855694.1 NZ_CP091997:2956240-2956530 [Salmonella enterica subsp. enterica serovar Kentucky]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Nucleotide

• Length: 291 bp

>AT235377 NZ_LR134244:809041-809334 [Staphylococcus warneri]
GTGACAGAACAAGATCATGCACATCACTCTGAACAAATTAAAGTCAATTTAAAATCGAGATTAAACCGAATTGAAGGTCA
AGTTAGAGCTATTAATCGAATGATAGAAGAGGATGTTTATTGCGATGATGTGTTAACTCAAATTAGAGCTACACGTTCTG
CATTAAATAGTGTAGCTACTAAATTATTAGAACAACATATGAAAAGTTGTATAGCAGATAAAGTAAATCAAGGTCATCAA
GAAGAAGCAATGGAGGAACTACTCGTTACGTTTCAAAAATTAATGAAAGATTGA

Structures

Toxin

• AlphaFold DB: A0A3G3DUX8

Antitoxin

• AlphaFold DB: A0A3V8SJE7