Detailed information of TA system TA023537

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbE-relB/ParE-YafN
• Location: 3148402..3148930
• Replicon: chromosome
• Accession: NC_011989
• Organism: Agrobacterium vitis S4

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: B9JS95
• Locus tag: AVI_RS14940
• Protein ID: WP_015917135.1
• Coordinates: 3148640..3148930 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B9JS94
• Locus tag: AVI_RS14935
• Protein ID: WP_015917134.1
• Coordinates: 3148402..3148650 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AVI_RS14910	3145219..3145785	+	567	WP_015917129.1	sarcosine oxidase subunit gamma	-
AVI_RS14915	3146108..3147169	-	1062	WP_015917130.1	SDR family oxidoreductase	-
AVI_RS14920	3147268..3147660	+	393	WP_015917131.1	helix-turn-helix transcriptional regulator	-
AVI_RS14925	3147717..3147998	-	282	WP_015917132.1	type II toxin-antitoxin system YafQ family toxin	-
AVI_RS14930	3147985..3148245	-	261	WP_015917133.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
AVI_RS14935	3148402..3148650	+	249	WP_015917134.1	antitoxin	Antitoxin
AVI_RS14940	3148640..3148930	+	291	WP_015917135.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AVI_RS14945	3149289..3149756	+	468	WP_015917136.1	hypothetical protein	-
AVI_RS14950	3149874..3150146	+	273	WP_015917137.1	BrnT family toxin	-
AVI_RS14955	3150115..3150393	+	279	WP_041697087.1	helix-turn-helix domain-containing protein	-
AVI_RS14960	3150428..3151534	-	1107	WP_015917139.1	TRAP transporter substrate-binding protein	-
AVI_RS14965	3151736..3152500	+	765	WP_015917140.1	gamma-glutamyl-gamma-aminobutyrate hydrolase family protein	-
AVI_RS14970	3152651..3153610	-	960	WP_015917141.1	2-hydroxyacid dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11023.82 Da
• Isoelectric Point: 10.6241

>T23537 WP_015917135.1 NC_011989:3148640-3148930 [Agrobacterium vitis S4]
MSYELAFVDAALKEWRKLDHSVREQFKKKLAERCINPRVPSAQLSGAKDRYKIKLRGAGYRLVYEVRDKDIIIVVVAVGR
RDRSGVYKAAADRNLS

Nucleotide

• Length: 291 bp

>T23537 NC_011989:3148640-3148930 [Agrobacterium vitis S4]
ATGAGCTATGAGCTGGCATTTGTCGATGCCGCGCTGAAAGAATGGCGAAAGCTCGATCATAGCGTCAGAGAACAGTTCAA
GAAAAAACTCGCCGAACGTTGTATCAATCCGCGCGTACCCTCCGCACAACTCTCTGGCGCCAAGGATCGTTACAAGATCA
AGCTGCGCGGTGCTGGCTATCGGCTGGTTTATGAAGTGCGCGATAAAGACATCATCATTGTCGTTGTCGCGGTTGGCAGG
CGGGATCGTTCCGGCGTCTATAAGGCCGCCGCTGATCGAAATCTGTCGTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8743.98 Da
• Isoelectric Point: 4.2404

>AT23537 WP_015917134.1 NC_011989:3148402-3148650 [Agrobacterium vitis S4]
MTHIVLAEVTASVSELKKNPMGTVAAGDGAAVAILNRNEPAFYCVPASAYEAMIERLDDLELNAIADARANDRVVKVTLD
EL

Nucleotide

• Length: 249 bp

>AT23537 NC_011989:3148402-3148650 [Agrobacterium vitis S4]
ATGACCCACATTGTCCTTGCCGAAGTGACAGCCAGCGTGTCTGAGCTGAAAAAGAACCCGATGGGGACAGTCGCCGCAGG
CGATGGGGCGGCGGTGGCTATTCTCAATCGTAACGAACCTGCTTTCTATTGCGTTCCGGCGTCAGCCTATGAAGCCATGA
TCGAACGGCTGGACGATCTCGAACTCAATGCCATTGCTGATGCGCGGGCGAATGATCGCGTCGTGAAGGTTACGCTGGAT
GAGCTATGA

Structures

Toxin

• AlphaFold DB: B9JS95

Antitoxin

• AlphaFold DB: B9JS94