235368

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 1561989..1562511 Replicon chromosome
Accession NZ_CP091997
Organism Salmonella enterica subsp. enterica serovar Kentucky strain N20-2289

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag MA641_RS07550 Protein ID WP_000221345.1
Coordinates 1561989..1562273 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag MA641_RS07555 Protein ID WP_000885424.1
Coordinates 1562263..1562511 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MA641_RS07530 (1558064) 1558064..1559572 - 1509 WP_023223898.1 FAD-dependent oxidoreductase -
MA641_RS07535 (1559617) 1559617..1560105 + 489 WP_023223899.1 MarR family winged helix-turn-helix transcriptional regulator -
MA641_RS07540 (1560298) 1560298..1561377 + 1080 WP_023203126.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
MA641_RS07545 (1561429) 1561429..1561818 - 390 WP_000194089.1 RidA family protein -
MA641_RS07550 (1561989) 1561989..1562273 - 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MA641_RS07555 (1562263) 1562263..1562511 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MA641_RS07560 (1562663) 1562663..1562782 + 120 Protein_1480 type II and III secretion system -
MA641_RS07565 (1562868) 1562868..1563199 + 332 Protein_1481 DUF1493 family protein -
MA641_RS07570 (1563472) 1563472..1564380 + 909 WP_077906523.1 hypothetical protein -
MA641_RS07575 (1564382) 1564382..1565121 - 740 Protein_1483 hypothetical protein -
MA641_RS07580 (1565487) 1565487..1565675 - 189 WP_001276021.1 DUF29 family protein -
MA641_RS07585 (1566077) 1566077..1566982 + 906 WP_102603908.1 nitronate monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1560298..1568700 8402


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T235368 WP_000221345.1 NZ_CP091997:c1562273-1561989 [Salmonella enterica subsp. enterica serovar Kentucky]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

>T235368 NZ_LR134242:51708-51962 [Staphylococcus warneri]
ATGGCAATAGTATCGTACTCAATAGCTAGAAAAAATTTTAGAAGTTTAATAGATAAAGTTAACAATGATTCAGATGCGGT
GACTATAACAACTAATGATAGCAATGCTGTACTGATTTCGGAGTCAGATTACAATGCGATGATGGAGACATTATACCTCC
AACAATCCCCTGCTAATGCGCAACACTTGGCTAAATCTATAGAAGATGTTGAGCGTGGAAATACAATAGAGGTAGATTTA
GAATCATATGAGTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT235368 WP_000885424.1 NZ_CP091997:c1562511-1562263 [Salmonella enterica subsp. enterica serovar Kentucky]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT235368 NZ_LR134242:51955-52218 [Staphylococcus warneri]
ATGAGTAGATTAAATATTTTATTTACACCTGATGCATTTGAAGATTATAAATATTGGCAAATTCATGATAAAAAATTATT
AAAAAAGATTAACCATTTAATAAAATGTATAAATCGTAATGGCCCACTCGAAGGTGAAGGAAAACCTGAAGCTTTGAAAG
GTAATTTTAAGGGATATTATAGTAGAAGAATCAATTTTGAACATAGGTTAGTTTATAAAGTACATGATTCAGAAATAATT
ATTGTTTCTTGTAAATATCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References