Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 571023..571643 Replicon chromosome
Accession NZ_CP091997
Organism Salmonella enterica subsp. enterica serovar Kentucky strain N20-2289

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag MA641_RS02675 Protein ID WP_001280991.1
Coordinates 571023..571241 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag MA641_RS02680 Protein ID WP_000344807.1
Coordinates 571269..571643 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MA641_RS02635 (566246) 566246..566815 + 570 WP_000779802.1 YbaY family lipoprotein -
MA641_RS02640 (566848) 566848..567237 - 390 WP_023224410.1 MGMT family protein -
MA641_RS02650 (567468) 567468..569018 - 1551 WP_000213145.1 EAL domain-containing protein -
MA641_RS02655 (569243) 569243..569503 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
MA641_RS02660 (569509) 569509..569649 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
MA641_RS02665 (569705) 569705..570175 - 471 WP_000136183.1 YlaC family protein -
MA641_RS02670 (570293) 570293..570844 - 552 WP_001278793.1 maltose O-acetyltransferase -
MA641_RS02675 (571023) 571023..571241 - 219 WP_001280991.1 HHA domain-containing protein Toxin
MA641_RS02680 (571269) 571269..571643 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
MA641_RS02685 (572139) 572139..575288 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
MA641_RS02690 (575311) 575311..576504 - 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T235367 WP_001280991.1 NZ_CP091997:c571241-571023 [Salmonella enterica subsp. enterica serovar Kentucky]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T235367 NZ_LR134240:c4270053-4269880 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT235367 WP_000344807.1 NZ_CP091997:c571643-571269 [Salmonella enterica subsp. enterica serovar Kentucky]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT235367 NZ_LR134240:c4270377-4270081 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References