Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 5259995..5260511 Replicon chromosome
Accession NZ_CP091992
Organism Klebsiella pneumoniae strain NB04

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag MA881_RS28535 Protein ID WP_002886902.1
Coordinates 5260227..5260511 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag MA881_RS28530 Protein ID WP_002886901.1
Coordinates 5259995..5260237 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MA881_RS28515 5256024..5256764 + 741 WP_002886899.1 KDGP aldolase family protein -
MA881_RS28520 5256830..5257984 + 1155 WP_002886900.1 lactonase family protein -
MA881_RS28525 5258007..5259917 + 1911 WP_004152270.1 PRD domain-containing protein -
MA881_RS28530 5259995..5260237 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MA881_RS28535 5260227..5260511 + 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MA881_RS28540 5260515..5260979 - 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MA881_RS28545 5261220..5263358 - 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
MA881_RS28550 5263715..5264458 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
MA881_RS28555 5264461..5264634 - 174 WP_002886906.1 hypothetical protein -
MA881_RS28560 5264719..5265027 + 309 WP_002886907.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T235363 WP_002886902.1 NZ_CP091992:5260227-5260511 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T235363 NZ_LR134240:c3715921-3715523 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT235363 WP_002886901.1 NZ_CP091992:5259995-5260237 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT235363 NZ_LR134240:c3716217-3715924 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATTACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References