Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
Location | 4782275..4782900 | Replicon | chromosome |
Accession | NZ_CP091992 | ||
Organism | Klebsiella pneumoniae strain NB04 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | R4Y4A3 |
Locus tag | MA881_RS26245 | Protein ID | WP_002882817.1 |
Coordinates | 4782517..4782900 (+) | Length | 128 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | J2DFR0 |
Locus tag | MA881_RS26240 | Protein ID | WP_004150355.1 |
Coordinates | 4782275..4782517 (+) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MA881_RS26215 | 4778266..4778865 | + | 600 | WP_004151865.1 | glucose-1-phosphatase | - |
MA881_RS26220 | 4778859..4779719 | + | 861 | WP_002882807.1 | virulence factor BrkB family protein | - |
MA881_RS26225 | 4779716..4780153 | + | 438 | WP_002882809.1 | D-aminoacyl-tRNA deacylase | - |
MA881_RS26230 | 4780198..4781139 | + | 942 | WP_004178031.1 | fatty acid biosynthesis protein FabY | - |
MA881_RS26235 | 4781153..4782070 | - | 918 | WP_002882812.1 | alpha/beta hydrolase | - |
MA881_RS26240 | 4782275..4782517 | + | 243 | WP_004150355.1 | CopG family transcriptional regulator | Antitoxin |
MA881_RS26245 | 4782517..4782900 | + | 384 | WP_002882817.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
MA881_RS26250 | 4783074..4784003 | - | 930 | WP_004150358.1 | formate dehydrogenase accessory protein FdhE | - |
MA881_RS26255 | 4784000..4784635 | - | 636 | WP_002882818.1 | formate dehydrogenase cytochrome b556 subunit | - |
MA881_RS26260 | 4784632..4785534 | - | 903 | WP_002882822.1 | formate dehydrogenase subunit beta | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 128 a.a. Molecular weight: 14377.62 Da Isoelectric Point: 7.3178
>T235361 WP_002882817.1 NZ_CP091992:4782517-4782900 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE
Download Length: 384 bp
>T235361 NZ_LR134240:2704553-2704660 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9567.83 Da Isoelectric Point: 4.3509
>AT235361 WP_004150355.1 NZ_CP091992:4782275-4782517 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW
Download Length: 243 bp
>AT235361 NZ_LR134240:c2704506-2704440 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GPK8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GGU9 |