Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3830651..3831308 Replicon chromosome
Accession NZ_CP091992
Organism Klebsiella pneumoniae strain NB04

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag MA881_RS21465 Protein ID WP_002916310.1
Coordinates 3830651..3831061 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag MA881_RS21470 Protein ID WP_002916312.1
Coordinates 3831042..3831308 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MA881_RS21445 3826651..3828384 - 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -
MA881_RS21450 3828390..3829103 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MA881_RS21455 3829126..3830022 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
MA881_RS21460 3830123..3830644 + 522 WP_002916308.1 flavodoxin FldB -
MA881_RS21465 3830651..3831061 - 411 WP_002916310.1 protein YgfX Toxin
MA881_RS21470 3831042..3831308 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
MA881_RS21475 3831554..3832537 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
MA881_RS21480 3832688..3833347 - 660 WP_002916317.1 hemolysin III family protein -
MA881_RS21485 3833511..3833822 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
MA881_RS21490 3833872..3834600 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
MA881_RS21495 3834719..3836152 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T235357 WP_002916310.1 NZ_CP091992:c3831061-3830651 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T235357 NZ_LR134240:2276202-2276489 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT235357 WP_002916312.1 NZ_CP091992:c3831308-3831042 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT235357 NZ_LR134240:2275963-2276202 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References