Detailed information of TA system TA235344

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 742457..743094
• Replicon: chromosome
• Accession: NZ_CP091985
• Organism: Burkholderia vietnamiensis strain FDAARGOS_721

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FOC29_RS19390
• Protein ID: WP_226146005.1
• Coordinates: 742457..742858 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: -
• Locus tag: FOC29_RS19395
• Protein ID: WP_011882846.1
• Coordinates: 742858..743094 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC29_RS19380 (FOC29_19370)	739834..740970	+	1137	WP_045578623.1	alginate lyase family protein	-
FOC29_RS19385 (FOC29_19375)	741001..742389	+	1389	WP_059568060.1	L-serine ammonia-lyase	-
FOC29_RS19390 (FOC29_19380)	742457..742858	-	402	WP_226146005.1	type II toxin-antitoxin system VapC family toxin	Toxin
FOC29_RS19395 (FOC29_19385)	742858..743094	-	237	WP_011882846.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
FOC29_RS19400 (FOC29_19390)	743373..745076	+	1704	WP_069246103.1	thiamine pyrophosphate-binding protein	-
FOC29_RS19405 (FOC29_19395)	745073..746194	+	1122	WP_176323253.1	ADP-heptose--LPS heptosyltransferase	-
FOC29_RS19410 (FOC29_19400)	746404..747438	-	1035	WP_034192975.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-119)

Antitoxin

• SpoVT-AbrB domain (7-44)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14892.01 Da
• Isoelectric Point: 5.1684

>T235344 WP_226146005.1 NZ_CP091985:c742858-742457 [Burkholderia vietnamiensis]
MPRYMLDTNMCIYLMKSQPEQVAKRFAQCYTGDVVMSAITYAELEYGVTACAAPARERRHLAALIEDIPVAPFDAAAAQA
YGPVRDATRAWKKDHLDKLIAAHAVSLDVVPVTNDERDFTSYPGLRLENWLND

Nucleotide

• Length: 402 bp

>T235344 NZ_LR134239:3520919-3521197 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9021.21 Da
• Isoelectric Point: 7.2056

>AT235344 WP_011882846.1 NZ_CP091985:c743094-742858 [Burkholderia vietnamiensis]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERIGDEIRIRPARRPLTQVLKKFAKFAPDFMAEGRGDHEQAEREGL

Nucleotide

• Length: 237 bp

>AT235344 NZ_LR134239:3520656-3520916 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA