Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2464411..2465030 Replicon chromosome
Accession NZ_CP091978
Organism Klebsiella pneumoniae isolate JNQH373

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag L6V94_RS11935 Protein ID WP_002892050.1
Coordinates 2464411..2464629 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag L6V94_RS11940 Protein ID WP_002892066.1
Coordinates 2464656..2465030 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6V94_RS11900 (2460456) 2460456..2460719 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
L6V94_RS11905 (2460719) 2460719..2460859 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
L6V94_RS11910 (2460856) 2460856..2461554 - 699 WP_002892021.1 GNAT family protein -
L6V94_RS11915 (2461655) 2461655..2463106 + 1452 WP_014907971.1 PLP-dependent aminotransferase family protein -
L6V94_RS11920 (2463081) 2463081..2463551 - 471 WP_002892026.1 YlaC family protein -
L6V94_RS11925 (2463572) 2463572..2463712 + 141 WP_004147370.1 hypothetical protein -
L6V94_RS11930 (2463684) 2463684..2464252 - 569 Protein_2310 maltose O-acetyltransferase -
L6V94_RS11935 (2464411) 2464411..2464629 - 219 WP_002892050.1 HHA domain-containing protein Toxin
L6V94_RS11940 (2464656) 2464656..2465030 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
L6V94_RS11945 (2465516) 2465516..2468662 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
L6V94_RS11950 (2468685) 2468685..2469878 - 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T235329 WP_002892050.1 NZ_CP091978:c2464629-2464411 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T235329 NZ_LR134239:180819-180926 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT235329 WP_002892066.1 NZ_CP091978:c2465030-2464656 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT235329 NZ_LR134239:c180771-180705 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References