Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1776554..1777070 Replicon chromosome
Accession NZ_CP091978
Organism Klebsiella pneumoniae isolate JNQH373

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag L6V94_RS08665 Protein ID WP_004178374.1
Coordinates 1776786..1777070 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag L6V94_RS08660 Protein ID WP_002886901.1
Coordinates 1776554..1776796 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6V94_RS08645 (1772582) 1772582..1773322 + 741 WP_002886899.1 KDGP aldolase family protein -
L6V94_RS08650 (1773389) 1773389..1774543 + 1155 WP_012737230.1 lactonase family protein -
L6V94_RS08655 (1774566) 1774566..1776476 + 1911 WP_012737231.1 PRD domain-containing protein -
L6V94_RS08660 (1776554) 1776554..1776796 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
L6V94_RS08665 (1776786) 1776786..1777070 + 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L6V94_RS08670 (1777074) 1777074..1777538 - 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
L6V94_RS08675 (1777867) 1777867..1780005 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
L6V94_RS08680 (1780362) 1780362..1781105 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
L6V94_RS08685 (1781108) 1781108..1781281 - 174 WP_041169004.1 hypothetical protein -
L6V94_RS08690 (1781411) 1781411..1781674 + 264 WP_014908078.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T235327 WP_004178374.1 NZ_CP091978:1776786-1777070 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T235327 NZ_LR134237:c4643639-4643466 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTTCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT235327 WP_002886901.1 NZ_CP091978:1776554-1776796 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT235327 NZ_LR134237:c4643963-4643667 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAACTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References