Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 429937..430594 Replicon chromosome
Accession NZ_CP091978
Organism Klebsiella pneumoniae isolate JNQH373

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag L6V94_RS02095 Protein ID WP_002916310.1
Coordinates 429937..430347 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag L6V94_RS02100 Protein ID WP_002916312.1
Coordinates 430328..430594 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6V94_RS02075 (425937) 425937..427670 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
L6V94_RS02080 (427676) 427676..428389 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
L6V94_RS02085 (428412) 428412..429308 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
L6V94_RS02090 (429409) 429409..429930 + 522 WP_002916308.1 flavodoxin FldB -
L6V94_RS02095 (429937) 429937..430347 - 411 WP_002916310.1 protein YgfX Toxin
L6V94_RS02100 (430328) 430328..430594 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
L6V94_RS02105 (430840) 430840..431823 + 984 WP_014906951.1 tRNA-modifying protein YgfZ -
L6V94_RS02110 (431922) 431922..432581 - 660 WP_002916317.1 hemolysin III family protein -
L6V94_RS02115 (432745) 432745..433056 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
L6V94_RS02120 (433106) 433106..433834 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
L6V94_RS02125 (433953) 433953..435386 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T235323 WP_002916310.1 NZ_CP091978:c430347-429937 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T235323 NZ_LR134237:c4262510-4262196 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT235323 WP_002916312.1 NZ_CP091978:c430594-430328 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT235323 NZ_LR134237:c4262746-4262513 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References