Detailed information of TA system TA235320

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3978893..3979524
• Replicon: chromosome
• Accession: NZ_CP091977
• Organism: Aromatoleum aromaticum strain pCyN1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q5P627
• Locus tag: L8M16_RS19020
• Protein ID: WP_011236958.1
• Coordinates: 3979141..3979524 (+)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: L8M16_RS19015
• Protein ID: WP_248280493.1
• Coordinates: 3978893..3979144 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L8M16_RS18980	3975568..3976098	-	531	WP_251199511.1	hypothetical protein	-
L8M16_RS18985	3976379..3976795	+	417	WP_011236951.1	pilin	-
L8M16_RS18990	3976988..3977185	+	198	WP_241762814.1	hypothetical protein	-
L8M16_RS18995	3977246..3977518	+	273	WP_011236953.1	DUF1778 domain-containing protein	-
L8M16_RS19000	3977515..3978009	+	495	WP_011236954.1	GNAT family N-acetyltransferase	-
L8M16_RS19005	3978209..3978523	+	315	WP_011236955.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
L8M16_RS19010	3978526..3978810	+	285	WP_011236956.1	type II toxin-antitoxin system RelE/ParE family toxin	-
L8M16_RS19015	3978893..3979144	+	252	WP_248280493.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
L8M16_RS19020	3979141..3979524	+	384	WP_011236958.1	twitching motility protein PilT	Toxin
L8M16_RS19025	3979521..3980051	-	531	WP_168953773.1	GNAT family N-acetyltransferase	-
L8M16_RS19030	3980048..3980329	-	282	WP_168953774.1	DUF1778 domain-containing protein	-
L8M16_RS19035	3980453..3981058	-	606	WP_041645864.1	EAL domain-containing protein	-
L8M16_RS19040	3981506..3981784	+	279	WP_041645866.1	DUF1778 domain-containing protein	-
L8M16_RS19045	3981781..3982380	+	600	WP_248280492.1	GNAT family N-acetyltransferase	-
L8M16_RS19050	3982389..3983222	-	834	WP_157866583.1	NAD(+) diphosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (17-59)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14205.70 Da
• Isoelectric Point: 6.2186

>T235320 WP_011236958.1 NZ_CP091977:3979141-3979524 [Aromatoleum aromaticum]
MKGVLVDTSIWVDHFRQRNDVLVGLLDLDLALTHPMVLVELACRTPPAPRVRTLGDIGLLQQTQQASLREVMDFIEREKL
YGLGCGLVDMVLLASTLITPGAELWTLDKRLAALSERFSVMHQPISR

Nucleotide

• Length: 384 bp

>T235320 NZ_LR134237:c3113754-3113374 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGTCCCGTCGCAGTTAATCAACAGCATCGATATTCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCTGGGCAGGCATCCGGAGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9433.76 Da
• Isoelectric Point: 5.0992

>AT235320 WP_248280493.1 NZ_CP091977:3978893-3979144 [Aromatoleum aromaticum]
MHILTHNDIFTDDGVRMRTTVTIDDDLYEKALEVADPAMDRADLFREAMKTFVRVQAAKRLAALGGTMPEMQDVPRRRGE
PSQ

Nucleotide

• Length: 252 bp

>AT235320 NZ_LR134237:c3114175-3113801 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Structures

Toxin

• AlphaFold DB: Q5P627