Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-vapB/-
Location 3978526..3979144 Replicon chromosome
Accession NZ_CP091977
Organism Aromatoleum aromaticum strain pCyN1

Toxin (Protein)


Gene name relE Uniprot ID Q5P629
Locus tag L8M16_RS19010 Protein ID WP_011236956.1
Coordinates 3978526..3978810 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L8M16_RS19015 Protein ID WP_248280493.1
Coordinates 3978893..3979144 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L8M16_RS18975 3973890..3975401 - 1512 WP_011236949.1 PHB depolymerase family esterase -
L8M16_RS18980 3975568..3976098 - 531 WP_251199511.1 hypothetical protein -
L8M16_RS18985 3976379..3976795 + 417 WP_011236951.1 pilin -
L8M16_RS18990 3976988..3977185 + 198 WP_241762814.1 hypothetical protein -
L8M16_RS18995 3977246..3977518 + 273 WP_011236953.1 DUF1778 domain-containing protein -
L8M16_RS19000 3977515..3978009 + 495 WP_011236954.1 GNAT family N-acetyltransferase -
L8M16_RS19005 3978209..3978523 + 315 WP_011236955.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
L8M16_RS19010 3978526..3978810 + 285 WP_011236956.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L8M16_RS19015 3978893..3979144 + 252 WP_248280493.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
L8M16_RS19020 3979141..3979524 + 384 WP_011236958.1 twitching motility protein PilT -
L8M16_RS19025 3979521..3980051 - 531 WP_168953773.1 GNAT family N-acetyltransferase -
L8M16_RS19030 3980048..3980329 - 282 WP_168953774.1 DUF1778 domain-containing protein -
L8M16_RS19035 3980453..3981058 - 606 WP_041645864.1 EAL domain-containing protein -
L8M16_RS19040 3981506..3981784 + 279 WP_041645866.1 DUF1778 domain-containing protein -
L8M16_RS19045 3981781..3982380 + 600 WP_248280492.1 GNAT family N-acetyltransferase -
L8M16_RS19050 3982389..3983222 - 834 WP_157866583.1 NAD(+) diphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-92)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(17-59)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10457.10 Da        Isoelectric Point: 4.6386

>T235319 WP_011236956.1 NZ_CP091977:3978526-3978810 [Aromatoleum aromaticum]
MGIVWTEEAIGDLEEILAYYYAEAGPATAQAVEERIVAEIMALTTFPERIRTSDRVPGARELVVRRLPYVVFVKGVPDGV
VVLNVVHTARKFPE

Download         Length: 285 bp

>T235319 NZ_LR134237:2905919-2906026 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCGTGATTTTCTGGCACGACCTGGCAGCACCGATCCTTGCGGGAATTATTACCGCAGCGAT
TGTTGGCTGGTGGCGTAGCCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.76 Da        Isoelectric Point: 5.0992

>AT235319 WP_248280493.1 NZ_CP091977:3978893-3979144 [Aromatoleum aromaticum]
MHILTHNDIFTDDGVRMRTTVTIDDDLYEKALEVADPAMDRADLFREAMKTFVRVQAAKRLAALGGTMPEMQDVPRRRGE
PSQ

Download         Length: 252 bp

>AT235319 NZ_LR134237:c2905863-2905802 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTGACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q5P629

Antitoxin

Source ID Structure

References