Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 3711846..3712456 Replicon chromosome
Accession NZ_CP091977
Organism Aromatoleum aromaticum strain pCyN1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag L8M16_RS17765 Protein ID WP_041645754.1
Coordinates 3711846..3712025 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag L8M16_RS17770 Protein ID WP_041645757.1
Coordinates 3712037..3712456 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L8M16_RS17745 3707652..3708881 + 1230 WP_168954949.1 chorismate-binding protein -
L8M16_RS17750 3709408..3710978 + 1571 WP_251199503.1 IS3-like element ISAzo10 family transposase -
L8M16_RS17755 3711070..3711390 - 321 WP_168955024.1 hypothetical protein -
L8M16_RS17760 3711377..3711658 - 282 WP_041645751.1 hypothetical protein -
L8M16_RS17765 3711846..3712025 + 180 WP_041645754.1 type II toxin-antitoxin system HicA family toxin Toxin
L8M16_RS17770 3712037..3712456 + 420 WP_041645757.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
L8M16_RS17775 3712653..3713744 + 1092 WP_011236701.1 hypothetical protein -
L8M16_RS17780 3714022..3714276 + 255 WP_011236703.1 DUF2442 domain-containing protein -
L8M16_RS17785 3714720..3714998 + 279 WP_011236705.1 type II toxin-antitoxin system RelE/ParE family toxin -
L8M16_RS17790 3715008..3715325 + 318 WP_011236706.1 HigA family addiction module antitoxin -
L8M16_RS17800 3716949..3717158 + 210 WP_251199504.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3707652..3735904 28252
- inside IScluster/Tn - - 3709477..3716798 7321


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-64)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6434.55 Da        Isoelectric Point: 11.2470

>T235317 WP_041645754.1 NZ_CP091977:3711846-3712025 [Aromatoleum aromaticum]
MNSKQMKKWLEQQGATFAPGKGSHLKVFLNGRQSSLPMHGTAELGKGLEAAIKRQLGLK

Download         Length: 180 bp

>T235317 NZ_LR134237:2261958-2262060 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15257.35 Da        Isoelectric Point: 4.7532

>AT235317 WP_041645757.1 NZ_CP091977:3712037-3712456 [Aromatoleum aromaticum]
MFDYPVVLTPDENGTVLVTFPDVPEAITFGADEDEALLLAVDALETGLSFYVDARKPLPTPSSAQGRPTVRPSALECAKL
GVYQAMTEQGLRKTDLARRLGWHLPQVDRLFDLSHASRFDQLEAAARALGRHIEVRVAP

Download         Length: 420 bp

>AT235317 NZ_LR134237:c2262098-2261830 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References