Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 2650562..2651255 Replicon chromosome
Accession NZ_CP091977
Organism Aromatoleum aromaticum strain pCyN1

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag L8M16_RS12670 Protein ID WP_168954738.1
Coordinates 2650562..2650939 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag L8M16_RS12675 Protein ID WP_168954740.1
Coordinates 2650920..2651255 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L8M16_RS12655 2647615..2648112 - 498 WP_083783003.1 FAD-dependent oxidoreductase -
L8M16_RS12660 2648228..2648653 - 426 Protein_2491 IS200/IS605 family transposase -
L8M16_RS12665 2649000..2650106 - 1107 WP_168954736.1 glycosyltransferase -
L8M16_RS12670 2650562..2650939 + 378 WP_168954738.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L8M16_RS12675 2650920..2651255 + 336 WP_168954740.1 helix-turn-helix transcriptional regulator Antitoxin
L8M16_RS12680 2651436..2652698 + 1263 WP_251199466.1 hypothetical protein -
L8M16_RS12685 2652760..2653272 + 513 WP_168955075.1 hypothetical protein -
L8M16_RS12690 2653406..2654995 - 1590 WP_251199467.1 J domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(18-97)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13736.83 Da        Isoelectric Point: 8.8594

>T235314 WP_168954738.1 NZ_CP091977:2650562-2650939 [Aromatoleum aromaticum]
MADKEKPLEWIASSYKDLMALPPDVRRRFGYALSLAQMGDQDDAAKVLKGFGGAGVLEVVEDDAGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKADMDIIRSRLKVAEAMAQELRNAKTNH

Download         Length: 378 bp

>T235314 NZ_LR134237:1987443-1987694 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12187.34 Da        Isoelectric Point: 10.5376

>AT235314 WP_168954740.1 NZ_CP091977:2650920-2651255 [Aromatoleum aromaticum]
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRKAIRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPASEPVGHLTLATT

Download         Length: 336 bp

>AT235314 NZ_LR134237:1987691-1987945 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAAAACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References