Detailed information of TA system TA235314

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 2650562..2651255
• Replicon: chromosome
• Accession: NZ_CP091977
• Organism: Aromatoleum aromaticum strain pCyN1

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: L8M16_RS12670
• Protein ID: WP_168954738.1
• Coordinates: 2650562..2650939 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: L8M16_RS12675
• Protein ID: WP_168954740.1
• Coordinates: 2650920..2651255 (+)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L8M16_RS12655	2647615..2648112	-	498	WP_083783003.1	FAD-dependent oxidoreductase	-
L8M16_RS12660	2648228..2648653	-	426	Protein_2491	IS200/IS605 family transposase	-
L8M16_RS12665	2649000..2650106	-	1107	WP_168954736.1	glycosyltransferase	-
L8M16_RS12670	2650562..2650939	+	378	WP_168954738.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L8M16_RS12675	2650920..2651255	+	336	WP_168954740.1	helix-turn-helix transcriptional regulator	Antitoxin
L8M16_RS12680	2651436..2652698	+	1263	WP_251199466.1	hypothetical protein	-
L8M16_RS12685	2652760..2653272	+	513	WP_168955075.1	hypothetical protein	-
L8M16_RS12690	2653406..2654995	-	1590	WP_251199467.1	J domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (16-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (18-97)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13736.83 Da
• Isoelectric Point: 8.8594

>T235314 WP_168954738.1 NZ_CP091977:2650562-2650939 [Aromatoleum aromaticum]
MADKEKPLEWIASSYKDLMALPPDVRRRFGYALSLAQMGDQDDAAKVLKGFGGAGVLEVVEDDAGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKADMDIIRSRLKVAEAMAQELRNAKTNH

Nucleotide

• Length: 378 bp

>T235314 NZ_LR134237:1987443-1987694 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12187.34 Da
• Isoelectric Point: 10.5376

>AT235314 WP_168954740.1 NZ_CP091977:2650920-2651255 [Aromatoleum aromaticum]
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRKAIRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPASEPVGHLTLATT

Nucleotide

• Length: 336 bp

>AT235314 NZ_LR134237:1987691-1987945 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAAAACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA