Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 2210615..2211159 Replicon chromosome
Accession NZ_CP091977
Organism Aromatoleum aromaticum strain pCyN1

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag L8M16_RS10670 Protein ID WP_211160077.1
Coordinates 2210971..2211159 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag L8M16_RS10665 Protein ID WP_041646544.1
Coordinates 2210615..2210974 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L8M16_RS10640 2205985..2206599 - 615 WP_168954660.1 hypothetical protein -
L8M16_RS10645 2206691..2207023 - 333 WP_168954658.1 cupin domain-containing protein -
L8M16_RS10650 2207032..2207784 - 753 WP_168954656.1 SDR family oxidoreductase -
L8M16_RS10655 2207907..2209040 + 1134 WP_168954654.1 IS200/IS605 family element RNA-guided endonuclease TnpB -
L8M16_RS10660 2209373..2210530 + 1158 WP_168954652.1 PQQ-dependent sugar dehydrogenase -
L8M16_RS10665 2210615..2210974 + 360 WP_041646544.1 MbcA/ParS/Xre antitoxin family protein Antitoxin
L8M16_RS10670 2210971..2211159 + 189 WP_211160077.1 hypothetical protein Toxin
L8M16_RS10675 2211234..2211539 + 306 WP_011236214.1 hypothetical protein -
L8M16_RS10680 2211539..2211898 + 360 WP_011236213.1 IS66 family insertion sequence element accessory protein TnpB -
L8M16_RS10685 2211927..2213543 + 1617 WP_011236212.1 IS66-like element ISAzo19 family transposase -
L8M16_RS10690 2213483..2214154 + 672 WP_251199450.1 RES family NAD+ phosphorylase -
L8M16_RS10695 2214267..2214533 - 267 WP_011239255.1 Txe/YoeB family addiction module toxin -
L8M16_RS10700 2214527..2214769 - 243 WP_011239256.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(8-64)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 6708.63 Da        Isoelectric Point: 4.0105

>T235312 WP_211160077.1 NZ_CP091977:2210971-2211159 [Aromatoleum aromaticum]
VTDIWAAVGAEAPVVELAGDLVRLVESQEQIATNRLVDTLEEQALLESLLETSKPPLPQGKR

Download         Length: 189 bp

>T235312 NZ_LR134237:1000518-1000925 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 12749.85 Da        Isoelectric Point: 10.3723

>AT235312 WP_041646544.1 NZ_CP091977:2210615-2210974 [Aromatoleum aromaticum]
MSVAALRKPDATQVVTKALLNAGKEMGLTQAALGVVIGKDRTAISRNGIDPDSKAGELALLLIRAYRALFALVGGDAAQM
KHWMHTDNHHVGGVPAEQIRTVQGLLRVVEYLDAIRGRL

Download         Length: 360 bp

>AT235312 NZ_LR134237:1000271-1000537 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTTTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References