Detailed information of TA system TA235311

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2154156..2154790
• Replicon: chromosome
• Accession: NZ_CP091977
• Organism: Aromatoleum aromaticum strain pCyN1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: L8M16_RS10375
• Protein ID: WP_011239195.1
• Coordinates: 2154389..2154790 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q5NZI0
• Locus tag: L8M16_RS10370
• Protein ID: WP_011239194.1
• Coordinates: 2154156..2154389 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L8M16_RS10330	2149165..2149452	+	288	WP_041646540.1	DUF1778 domain-containing protein	-
L8M16_RS10335	2149449..2149940	+	492	WP_168954188.1	GNAT family N-acetyltransferase	-
L8M16_RS10340	2150024..2150314	+	291	WP_011239187.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
L8M16_RS10345	2150314..2150751	+	438	WP_011239188.1	putative toxin-antitoxin system toxin component, PIN family	-
L8M16_RS10350	2150957..2151295	+	339	WP_011239189.1	H-NS histone family protein	-
L8M16_RS10355	2151481..2151732	+	252	WP_011239190.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
L8M16_RS10360	2151761..2152048	+	288	WP_248280553.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	-
L8M16_RS10365	2153273..2153710	+	438	Protein_2031	O-antigen ligase family protein	-
L8M16_RS10370	2154156..2154389	+	234	WP_011239194.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
L8M16_RS10375	2154389..2154790	+	402	WP_011239195.1	tRNA(fMet)-specific endonuclease VapC	Toxin
L8M16_RS10380	2154997..2157582	-	2586	WP_168954186.1	[protein-PII] uridylyltransferase	-
L8M16_RS10385	2157589..2158410	-	822	WP_168954185.1	type I methionyl aminopeptidase	-
L8M16_RS10390	2158780..2159535	+	756	WP_168954184.1	30S ribosomal protein S2	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (7-56)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14679.98 Da
• Isoelectric Point: 8.9537

>T235311 WP_011239195.1 NZ_CP091977:2154389-2154790 [Aromatoleum aromaticum]
MLRYLLDTNIVIYVIKRRPLSALALFNVNAGHMAISSITLAELMHGAEKSNAPARSLAAVEDFCSRLEVLPYGPKAAMHY
GNIRARLESRGQTIGVNDLHIAAHARSEGLTLVSNNLREFERVEALQLANWAI

Nucleotide

• Length: 402 bp

>T235311 NZ_LR134237:c621928-621464 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGCGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAGCCATTGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8745.83 Da
• Isoelectric Point: 5.0022

>AT235311 WP_011239194.1 NZ_CP091977:2154156-2154389 [Aromatoleum aromaticum]
MTTTTVFTNNRSQAVRLPADMRLPANVKQVDIRARGLERIIAPVGHTWDSFFIDGPQVADDFMETRASQEQQEREAL

Nucleotide

• Length: 234 bp

>AT235311 NZ_LR134237:c622263-621928 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCTGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA

Structures

Antitoxin

• AlphaFold DB: Q5NZI0