Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2151481..2152048 Replicon chromosome
Accession NZ_CP091977
Organism Aromatoleum aromaticum strain pCyN1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag L8M16_RS10360 Protein ID WP_248280553.1
Coordinates 2151761..2152048 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q5NZI4
Locus tag L8M16_RS10355 Protein ID WP_011239190.1
Coordinates 2151481..2151732 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L8M16_RS10325 2148006..2148740 + 735 WP_011236010.1 IS21-like element ISAzo4 family helper ATPase IstB -
L8M16_RS10330 2149165..2149452 + 288 WP_041646540.1 DUF1778 domain-containing protein -
L8M16_RS10335 2149449..2149940 + 492 WP_168954188.1 GNAT family N-acetyltransferase -
L8M16_RS10340 2150024..2150314 + 291 WP_011239187.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
L8M16_RS10345 2150314..2150751 + 438 WP_011239188.1 putative toxin-antitoxin system toxin component, PIN family -
L8M16_RS10350 2150957..2151295 + 339 WP_011239189.1 H-NS histone family protein -
L8M16_RS10355 2151481..2151732 + 252 WP_011239190.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
L8M16_RS10360 2151761..2152048 + 288 WP_248280553.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
L8M16_RS10365 2153273..2153710 + 438 Protein_2031 O-antigen ligase family protein -
L8M16_RS10370 2154156..2154389 + 234 WP_011239194.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
L8M16_RS10375 2154389..2154790 + 402 WP_011239195.1 tRNA(fMet)-specific endonuclease VapC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-80)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-77)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11006.02 Da        Isoelectric Point: 9.7692

>T235310 WP_248280553.1 NZ_CP091977:2151761-2152048 [Aromatoleum aromaticum]
MKFLPEALAEWNALDGSVKEVLKKLLRKRLEQPRLPGAELHGDLRDCYKIKLLKQGYRLVYQVEDDVLVVLVLAVAKRED
MAVYRTAVDRLLSRQ

Download         Length: 288 bp

>T235310 NZ_LR134237:197057-197164 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9379.78 Da        Isoelectric Point: 4.7962

>AT235310 WP_011239190.1 NZ_CP091977:2151481-2151732 [Aromatoleum aromaticum]
MDAIYADFSVSMSEFKKNPAQVLRTAGEKPVAVLNHNRPAFYMVTPKLFEALLDELADRDLVELARQRVARKETAVEVDI
DTL

Download         Length: 252 bp

>AT235310 NZ_LR134237:c197008-196945 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB Q5NZI4

References