Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2149165..2149940 Replicon chromosome
Accession NZ_CP091977
Organism Aromatoleum aromaticum strain pCyN1

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag L8M16_RS10335 Protein ID WP_168954188.1
Coordinates 2149449..2149940 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag L8M16_RS10330 Protein ID WP_041646540.1
Coordinates 2149165..2149452 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L8M16_RS10295 2144253..2144732 + 480 WP_011239180.1 VanZ family protein -
L8M16_RS10300 2144747..2145013 + 267 WP_168955039.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
L8M16_RS10305 2145013..2145384 + 372 WP_211160130.1 type II toxin-antitoxin system RelE/ParE family toxin -
L8M16_RS10310 2145377..2145688 + 312 WP_011239183.1 helix-turn-helix transcriptional regulator -
L8M16_RS10315 2145730..2146173 + 444 WP_011239184.1 hypothetical protein -
L8M16_RS10320 2146424..2147983 + 1560 WP_251199588.1 IS21 family transposase -
L8M16_RS10325 2148006..2148740 + 735 WP_011236010.1 IS21-like element ISAzo4 family helper ATPase IstB -
L8M16_RS10330 2149165..2149452 + 288 WP_041646540.1 DUF1778 domain-containing protein Antitoxin
L8M16_RS10335 2149449..2149940 + 492 WP_168954188.1 GNAT family N-acetyltransferase Toxin
L8M16_RS10340 2150024..2150314 + 291 WP_011239187.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
L8M16_RS10345 2150314..2150751 + 438 WP_011239188.1 putative toxin-antitoxin system toxin component, PIN family -
L8M16_RS10350 2150957..2151295 + 339 WP_011239189.1 H-NS histone family protein -
L8M16_RS10355 2151481..2151732 + 252 WP_011239190.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
L8M16_RS10360 2151761..2152048 + 288 WP_248280553.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
L8M16_RS10365 2153273..2153710 + 438 Protein_2031 O-antigen ligase family protein -
L8M16_RS10370 2154156..2154389 + 234 WP_011239194.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
L8M16_RS10375 2154389..2154790 + 402 WP_011239195.1 tRNA(fMet)-specific endonuclease VapC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - tviB / bplB / cap8E 2087409..2149940 62531
- inside IScluster/Tn - - 2136643..2148740 12097


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(70-145)

Antitoxin

Vibrio phage ICP1, Orf50

(13-87)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17234.86 Da        Isoelectric Point: 8.2918

>T235309 WP_168954188.1 NZ_CP091977:2149449-2149940 [Aromatoleum aromaticum]
VSLTAPEPLTAHHDTSAFACGVESLDHWLKQRALKNQASGASRTFVVCEGKRVLAYYALASSAVAAEAATGRLRRNMPDP
IPVVVLGRLAIDRSLQGGGIGRALVRDACLRVLAAADAIGIRGMIVHALSESARAFYERAGFDPSPLDPMTLMATIADLR
EGP

Download         Length: 492 bp

>T235309 NZ_LR134237:c47348-46923 [Escherichia coli]
ATGAAAATTATTCCTGCAACGACGCTGCGGGCGACGACGTCATATCTGTCGCCTGTCGTGGTCTGGCAAACATTACTGGC
CCGCCTGCTGGAGCAGCACTACGGGCTGAATCTTAATGACACACCATTCAACAATGAAAAGGTGATTCAGGAACACATAG
ACGCCGGGATCACTCTGGTCAATGCCGTCAATTTTCTGGTGGAGAAGTACGAATTGGTCCGTATCGACAGGAAAGGATTT
AGCTGGCAGGAACAGACGCCTTATCTTCGTGCGGTCGATATTTTGCGGGCGCGGCAGGCGACCGGCCTGCGGATTCAGTG
CAAAAACACGAATATAATCAGCCGGATGGCTGATTCAAGACATGATAAAAGACTTTACCAGCGCACGTTTAAAGCGTGCA
AGAGATGTTATTATACTAAAACATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10703.27 Da        Isoelectric Point: 10.4623

>AT235309 WP_041646540.1 NZ_CP091977:2149165-2149452 [Aromatoleum aromaticum]
MSAANSIAKRDTLNLRIKPEVRGLIDRAAKVRGKNRTDFILDAARNAAEEALLDQALFLVSEDAYAEFVERLDRSPALNP
RLKKTLQTPAPWDKR

Download         Length: 288 bp

>AT235309 NZ_LR134237:c47714-47379 [Escherichia coli]
ATGCTGCAAAAGGACAAGGTCATGCAACAAGAATGGGGGCTTCCCTGTACCGTAACACCACGCTTCACTGCTCGACTGGT
ACAGGAAAGACATAACCTGCATTACCTGGCTGATCGGGCCGCAATCACCGGGAAATTCAGCTCCCCGGATCTGCTGCATA
TCGACCAGGCTTTTCCGGTGTTGATGAAACAACTGGAGCTGAAACTGGCTGACGGTGAACTCTCCCCCTGCCAACAACGT
ACCGTCACGCTATACGCCAAAGGACTAACCTGCGAAGCCGATACGCTGGGTTCCTGTGGTTACGTCTATATCGCTATTTA
TCCCACTCAACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References