Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 2094983..2095588 Replicon chromosome
Accession NZ_CP091977
Organism Aromatoleum aromaticum strain pCyN1

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag L8M16_RS10000 Protein ID WP_168954215.1
Coordinates 2094983..2095282 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag L8M16_RS10005 Protein ID WP_168954216.1
Coordinates 2095286..2095588 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L8M16_RS09965 2090490..2091080 + 591 WP_168954212.1 nucleotidyltransferase domain-containing protein -
L8M16_RS09970 2091070..2091507 + 438 WP_011239119.1 hypothetical protein -
L8M16_RS09975 2091567..2092094 + 528 WP_041646527.1 MBL fold metallo-hydrolase RNA specificity domain-containing protein -
L8M16_RS09980 2092227..2092472 + 246 Protein_1954 type II toxin-antitoxin system RelE/ParE family toxin -
L8M16_RS09985 2092752..2092985 + 234 WP_248280558.1 winged helix-turn-helix transcriptional regulator -
L8M16_RS09990 2093031..2093276 + 246 WP_168954213.1 DUF6364 family protein -
L8M16_RS09995 2093623..2094900 + 1278 WP_168954214.1 Vi polysaccharide biosynthesis UDP-N-acetylglucosamine C-6 dehydrogenase TviB -
L8M16_RS10000 2094983..2095282 + 300 WP_168954215.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L8M16_RS10005 2095286..2095588 + 303 WP_168954216.1 putative addiction module antidote protein Antitoxin
L8M16_RS10010 2095689..2096633 + 945 WP_168954217.1 Gfo/Idh/MocA family oxidoreductase -
L8M16_RS10015 2096639..2097223 + 585 WP_168954218.1 UDP-2-acetamido-3-amino-2, 3-dideoxy-D-glucuronate N-acetyltransferase -
L8M16_RS10020 2097224..2098309 + 1086 WP_168954219.1 DegT/DnrJ/EryC1/StrS family aminotransferase -
L8M16_RS10025 2098320..2099720 + 1401 WP_168954220.1 oligosaccharide flippase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - tviB / bplB / cap8E 2087409..2149940 62531


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-94)

Antitoxin

Uncharacterized protein HI1420

(13-97)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11008.70 Da        Isoelectric Point: 10.1452

>T235307 WP_168954215.1 NZ_CP091977:2094983-2095282 [Aromatoleum aromaticum]
MPSVKHTPEFDGWLNSLRDRPTRFRLLRRLEKAQRGLLGDVAPVGEGVFEMREFFGPGWRMYYLQRGEVLIVMLGGGDKS
SQAADIASAKALAATLKDG

Download         Length: 300 bp

>T235307 NZ_LR134236:4113977-4114234 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10893.60 Da        Isoelectric Point: 7.2780

>AT235307 WP_168954216.1 NZ_CP091977:2095286-2095588 [Aromatoleum aromaticum]
MSKPVKISDLPEFDMAEHLKTDADVAEYLRQVLEDGEPGELAAALGHIAKARGMTEIAKATGIKREALYKALRPNAHPRL
ETVQRVCKALGVKLTATVDN

Download         Length: 303 bp

>AT235307 NZ_LR134236:4114246-4114791 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTTAGCAAAGAAGCCGATTTAGTGACCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References