Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 2085997..2086608 Replicon chromosome
Accession NZ_CP091977
Organism Aromatoleum aromaticum strain pCyN1

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag L8M16_RS09940 Protein ID WP_241762754.1
Coordinates 2085997..2086296 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag L8M16_RS09945 Protein ID WP_041646526.1
Coordinates 2086306..2086608 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L8M16_RS09910 2082355..2082780 - 426 WP_011239111.1 RNA polymerase-binding protein DksA -
L8M16_RS09930 2083325..2084077 - 753 WP_168954801.1 hypothetical protein -
L8M16_RS09935 2084169..2085527 + 1359 WP_011236184.1 IS1182-like element ISAzo1 family transposase -
L8M16_RS09940 2085997..2086296 + 300 WP_241762754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L8M16_RS09945 2086306..2086608 + 303 WP_041646526.1 putative addiction module antidote protein Antitoxin
L8M16_RS09950 2087209..2087367 + 159 WP_157866636.1 hypothetical protein -
L8M16_RS09955 2087409..2088845 + 1437 WP_168954235.1 ATP-binding protein -
L8M16_RS09960 2088848..2090302 + 1455 WP_168954211.1 MBL fold metallo-hydrolase -
L8M16_RS09965 2090490..2091080 + 591 WP_168954212.1 nucleotidyltransferase domain-containing protein -
L8M16_RS09970 2091070..2091507 + 438 WP_011239119.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2084169..2085527 1358


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-99)

Antitoxin

Cro/C1-type helix-turn-helix domain

(48-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11023.72 Da        Isoelectric Point: 7.9987

>T235306 WP_241762754.1 NZ_CP091977:2085997-2086296 [Aromatoleum aromaticum]
MNGMKTVLTTEFFDAWFAELRDPQAAARIKMRIGRAELGNFGDCEPVGEGVSEMRIHYGPGYRLYFTQRGLEVVILLAGG
DKSSQAKDIKTALKLAREL

Download         Length: 300 bp

>T235306 NZ_LR134236:c4059593-4059306 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTGGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACTATCGGCG
TGGTTCACGGTATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAGTCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10777.43 Da        Isoelectric Point: 6.7188

>AT235306 WP_041646526.1 NZ_CP091977:2086306-2086608 [Aromatoleum aromaticum]
MALKLRKWDTAEHLKTEEEMALYLEACLEEAGDDAAFIAKALGDIARAKGMTQLAKDTGLGRESLYKALSGEGNPSFATI
LKVTRALGLQLHAAPRHAPV

Download         Length: 303 bp

>AT235306 NZ_LR134236:c4059319-4059017 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAATTGAAGGCGCTGGCGAA
TAAATCCGACGAAGAGATTGATTACAGCGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACCCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGCTGAAGCGACCTGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References