Detailed information of TA system TA235301

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1189247..1190805
• Replicon: chromosome
• Accession: NZ_CP091976
• Organism: Vibrio sp. DW001

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: L3V77_RS22710
• Protein ID: WP_275137091.1
• Coordinates: 1189501..1190805 (+)
• Length: 435 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: L3V77_RS22705
• Protein ID: WP_275137090.1
• Coordinates: 1189247..1189501 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L3V77_RS22690 (L3V77_22655)	1185346..1185561	+	216	WP_275137087.1	hypothetical protein	-
L3V77_RS22695 (L3V77_22660)	1185554..1187317	+	1764	WP_275137088.1	ABC transporter ATP-binding protein	-
L3V77_RS22700 (L3V77_22665)	1187311..1189095	+	1785	WP_275137089.1	ABC transporter ATP-binding protein	-
L3V77_RS22705 (L3V77_22670)	1189247..1189501	+	255	WP_275137090.1	helix-turn-helix domain-containing protein	Antitoxin
L3V77_RS22710 (L3V77_22675)	1189501..1190805	+	1305	WP_275137091.1	type II toxin-antitoxin system HipA family toxin	Toxin
L3V77_RS22715 (L3V77_22680)	1190911..1191015	+	105	Protein_1076	IS6 family transposase	-
L3V77_RS22720 (L3V77_22685)	1191246..1191647	+	402	WP_275137092.1	ACT domain-containing protein	-
L3V77_RS22725 (L3V77_22690)	1192069..1192791	+	723	WP_275137093.1	sulfite exporter TauE/SafE family protein	-
L3V77_RS22730 (L3V77_22695)	1193254..1194456	-	1203	WP_275137094.1	MFS transporter	-
L3V77_RS22735 (L3V77_22700)	1194599..1195480	+	882	WP_275137095.1	LysR family transcriptional regulator	-
L3V77_RS22740 (L3V77_22705)	1195668..1195745	+	78	WP_275138233.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 435 a.a.
• Molecular weight: 49007.69 Da
• Isoelectric Point: 8.8390

>T235301 WP_275137091.1 NZ_CP091976:1189501-1190805 [Vibrio sp. DW001]
MAILDVYLNGYLVGEFKKSSNGAHSFRYSNSWLALSGSRPISLSMPLAKSEYRGDVVYNYFDNLLPDNLEVRQRIVARYQ
AGSSLPFDLLSMIGRDCVGALQLLPKGEAPLNVKNLEYRALDNEELDKIIMGYRTDIPLGMIESLQNFRISVAGAQEKTA
LLNIAKAWYLPLNSTPTSHIIKLPIGQIQSHSYSLDMSDSVENEFLCMLLLEAYGLSVAGCEILTLEEMNVLSVERFDRQ
YSSDKKWLMRRPQEDYCQVFNTPSALKYENQGGPGIEQIMNHLLGSKSAAKDRYDFMKAQVLFWLMGASDGHAKNFSIYI
LPDGQFQLTPFYDVLSVFPIVNKKGLNIRQVKLAMGLKSTKGKKYHVNKIHPRHFIETAKQVGFETVKMESIISEIKAST
EQIIIDTQAKLAVNFPKNVSERIFSGMLKQLKKL

Nucleotide

• Length: 1305 bp

>T235301 NZ_LR134236:3103796-3104182 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGGCGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAAGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGGTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCAGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTCTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9614.76 Da
• Isoelectric Point: 4.8283

>AT235301 WP_275137090.1 NZ_CP091976:1189247-1189501 [Vibrio sp. DW001]
MKISTTKQLSAYLKDVRLDNELSQTDVAKKVGVRQDTVSNFELRAGSTKLDTFFKLLSALELDFEITPRNNKSSDDESGW
KEEW

Nucleotide

• Length: 255 bp

>AT235301 NZ_LR134236:3104172-3104501 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCATTGGGCCTGATGTCTGATAGTGAGGTTGA
TGCCATTGCCGTCATGGTCAAAGCCCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA