Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 690931..692771 Replicon chromosome
Accession NZ_CP091975
Organism Vibrio sp. DW001

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag L3V77_RS03385 Protein ID WP_275135731.1
Coordinates 691407..692771 (-) Length 455 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag L3V77_RS03380 Protein ID WP_275135730.1
Coordinates 690931..691422 (-) Length 164 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3V77_RS03350 (L3V77_03350) 687098..687886 + 789 WP_275135724.1 avidin/streptavidin family protein -
L3V77_RS03355 (L3V77_03355) 687902..688405 - 504 WP_275135725.1 YgjV family protein -
L3V77_RS03360 (L3V77_03360) 688551..688976 - 426 WP_275135726.1 GFA family protein -
L3V77_RS03365 (L3V77_03365) 689040..689408 - 369 WP_275135727.1 VOC family protein -
L3V77_RS03370 (L3V77_03370) 689628..690038 + 411 WP_275135728.1 hypothetical protein -
L3V77_RS03375 (L3V77_03375) 690085..690825 + 741 WP_275135729.1 SDR family oxidoreductase -
L3V77_RS03380 (L3V77_03380) 690931..691422 - 492 WP_275135730.1 helix-turn-helix transcriptional regulator Antitoxin
L3V77_RS03385 (L3V77_03385) 691407..692771 - 1365 WP_275135731.1 HipA domain-containing protein Toxin
L3V77_RS03390 (L3V77_03390) 693129..693602 + 474 WP_275135732.1 DUF1203 domain-containing protein -
L3V77_RS03395 (L3V77_03395) 693987..694886 - 900 WP_275135733.1 methyl-accepting chemotaxis protein -
L3V77_RS03400 (L3V77_03400) 694883..695176 - 294 WP_275135734.1 nitrate/nitrite transporter NrtS -
L3V77_RS03405 (L3V77_03405) 695291..696169 + 879 WP_275135735.1 AraC family transcriptional regulator -
L3V77_RS03410 (L3V77_03410) 696389..697720 + 1332 WP_275135736.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-386)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 455 a.a.        Molecular weight: 51674.41 Da        Isoelectric Point: 4.6197

>T235300 WP_275135731.1 NZ_CP091975:c692771-691407 [Vibrio sp. DW001]
MEELTIQAFTKEEWLDVAIISFPKSDKKNLSVTELHYLDDYALDHHNKDDLHAVSINHPVSFFFDDMGKPGWLKFLDDIM
PSGAGRRYWVKHLDIEDLTYDEQDYILLKFGTMSPVGNLRVKDSLPERHEVSDTLYFSVGDVLNRAGDFLDYAQQRGATA
GGATGAGGEAPKLLLRCSIEEDASDNKIWIDPYQDDDTNQDLHYLVKYPRGSRTTIDCNILRAEFYYYHELTEMGFDTIP
IENMRLEEGINYPSLWLPRFDIKFNDQQHIERFGMESVYSILGKGAGVTLDHEATIRALIEKITQSHMVSSQGYDFDIQD
FVIEWVKRDLLNILFGNSDNHGRNTSFLKGDGFIKLAPIYDFAPMKADPEGIPRTTKWRTPLEVGGTYDFIGIADLLSDL
VASEILLAELRSTAKQCLDLKKRLVDKGVPEQILEMPATGLNHISDKLTKWGLL

Download         Length: 1365 bp

>T235300 NZ_LR134236:2675636-2675743 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGGACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 164 a.a.        Molecular weight: 17992.58 Da        Isoelectric Point: 10.7160

>AT235300 WP_275135730.1 NZ_CP091975:c691422-690931 [Vibrio sp. DW001]
MGAVMSTNKPVSKESIQSTVARLRASREKASTTRSTTTEAIKNTDQSVQMTQRVSKNTTSVSTTDRKKAANHIIKRLLFS
ELTEGQALKELRINVLGLKQDVYAKLVNVSRKTLSDIENDRGNYKTDILNKVFKPFGLKAGLIPSSPSMLNSLIHGNETL
VED

Download         Length: 492 bp

>AT235300 NZ_LR134236:c2675586-2675523 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References