Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 18659..19008 Replicon plasmid p3_L201601331
Accession NZ_CP091966
Organism Leptospira noguchii strain 201601331

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MAL07_RS19835 Protein ID WP_279574428.1
Coordinates 18659..18757 (-) Length 33 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag MAL07_RS19840 Protein ID WP_243825609.1
Coordinates 18793..19008 (-) Length 72 a.a.

Genomic Context

MAL07_RS19795MAL07_RS19800MAL07_RS19805MAL07_RS19820MAL07_RS19825MAL07_RS19860MAL07_RS19865MAL07_RS19810MAL07_RS19815MAL07_RS19830MAL07_RS19835MAL07_RS19840MAL07_RS19845MAL07_RS19850MAL07_RS19855MAL07_RS19870MAL07_RS19875MAL07_RS19880
Location: 14639..14904 (266 bp)
Type: Others
Protein ID: Protein_19
Location: 15035..15379 (345 bp)
Type: Others
Protein ID: WP_243825608.1
Location: 15976..16165 (190 bp)
Type: Others
Protein ID: Protein_21
Location: 17745..18054 (310 bp)
Type: Others
Protein ID: Protein_24
Location: 18020..18393 (374 bp)
Type: Others
Protein ID: Protein_25
Location: 21284..21502 (219 bp)
Type: Others
Protein ID: WP_243825611.1
Location: 21439..21666 (228 bp)
Type: Others
Protein ID: WP_243825620.1
Location: 16427..16829 (403 bp)
Type: Others
Protein ID: Protein_22
Location: 16839..17072 (234 bp)
Type: Others
Protein ID: Protein_23
Location: 18487..18612 (126 bp)
Type: Others
Protein ID: WP_243825619.1
Location: 18659..18757 (99 bp)
Type: Toxin
Protein ID: WP_279574428.1
Location: 18793..19008 (216 bp)
Type: Antitoxin
Protein ID: WP_243825609.1
Location: 19522..19917 (396 bp)
Type: Others
Protein ID: WP_243825610.1
Location: 20027..20518 (492 bp)
Type: Others
Protein ID: Protein_30
Location: 20795..21215 (421 bp)
Type: Others
Protein ID: Protein_31
Location: 21797..22919 (1123 bp)
Type: Others
Protein ID: Protein_34
Location: 22919..23254 (336 bp)
Type: Others
Protein ID: WP_243825612.1
Location: 23534..23779 (246 bp)
Type: Others
Protein ID: WP_243825613.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MAL07_RS19795 (MAL07_19795)14639..14904+266Protein_19IS5/IS1182 family transposase-
MAL07_RS19800 (MAL07_19800)15035..15379+345WP_243825608.1hypothetical protein-
MAL07_RS19805 (MAL07_19805)15976..16165+190Protein_21IS5/IS1182 family transposase-
MAL07_RS19810 (MAL07_19810)16427..16829-403Protein_22putative toxin-antitoxin system toxin component, PIN family-
MAL07_RS19815 (MAL07_19815)16839..17072-234Protein_23ribbon-helix-helix domain-containing protein-
MAL07_RS19820 (MAL07_19820)17745..18054+310Protein_24hypothetical protein-
MAL07_RS19825 (MAL07_19825)18020..18393+374Protein_25hypothetical protein-
MAL07_RS19830 (MAL07_19830)18487..18612-126WP_243825619.1toxin-antitoxin system, toxin component, MazF family protein-
MAL07_RS19835 (MAL07_19835)18659..18757-99WP_279574428.1type II toxin-antitoxin system PemK/MazF family toxinToxin
MAL07_RS19840 (MAL07_19840)18793..19008-216WP_243825609.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
MAL07_RS19845 (MAL07_19845)19522..19917-396WP_243825610.1hypothetical protein-
MAL07_RS19850 (MAL07_19850)20027..20518-492Protein_30PD-(D/E)XK nuclease family protein-
MAL07_RS19855 (MAL07_19855)20795..21215-421Protein_31XRE family transcriptional regulator-
MAL07_RS19860 (MAL07_19860)21284..21502+219WP_243825611.1hypothetical protein-
MAL07_RS19865 (MAL07_19865)21439..21666+228WP_243825620.1helix-turn-helix transcriptional regulator-
MAL07_RS19870 (MAL07_19870)21797..22919-1123Protein_34restriction endonuclease-
MAL07_RS19875 (MAL07_19875)22919..23254-336WP_243825612.1hypothetical protein-
MAL07_RS19880 (MAL07_19880)23534..23779-246WP_243825613.1DNA methyltransferase-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..2848428484


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-30)

Antitoxin

SpoVT-AbrB domain

(2-41)


Sequences

Toxin        


Download         Length: 33 a.a.        Molecular weight: 3610.09 Da        Isoelectric Point: 10.6262

>T235294 WP_279574428.1 NZ_CP091966:c18757-18659 [Leptospira noguchii]
VWLNFTPQAGHEQKGRRPALVLSPKEYNSKTG

Download         Length: 99 bp

>T235294 NZ_LR134236:2070122-2070225 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7843.92 Da        Isoelectric Point: 5.6422

>AT235294 WP_243825609.1 NZ_CP091966:c19008-18793 [Leptospira noguchii]
MGNSLGIRIPKAMATELELNDGSHVELQYEGDKIVIYPMKKASLEDKLSKITKQNLHSEISTGNSIGNEAW

Download         Length: 216 bp

>AT235294 NZ_LR134236:c2070263-2069992 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
No matching records found

Antitoxin

Loading, please wait
Source
ID
Structure
No matching records found

References