Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 24315..24886 Replicon plasmid p2_L201601331
Accession NZ_CP091965
Organism Leptospira noguchii strain 201601331

Toxin (Protein)


Gene name mazF Uniprot ID Q8F5A3
Locus tag MAL07_RS19635 Protein ID WP_000240418.1
Coordinates 24315..24656 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M6U553
Locus tag MAL07_RS19640 Protein ID WP_000443825.1
Coordinates 24650..24886 (-) Length 79 a.a.

Genomic Context

MAL07_RS19605MAL07_RS19610MAL07_RS19625MAL07_RS19630MAL07_RS19655MAL07_RS19615MAL07_RS19620MAL07_RS19635MAL07_RS19640MAL07_RS19645MAL07_RS19650MAL07_RS19660MAL07_RS19665
Location: 20474..20740 (267 bp)
Type: Others
Protein ID: Protein_14
Location: 20886..22005 (1120 bp)
Type: Others
Protein ID: Protein_15
Location: 23597..23905 (309 bp)
Type: Others
Protein ID: WP_002148401.1
Location: 23871..24245 (375 bp)
Type: Others
Protein ID: Protein_19
Location: 27143..27523 (381 bp)
Type: Others
Protein ID: WP_235595273.1
Location: 22268..22672 (405 bp)
Type: Others
Protein ID: WP_004420606.1
Location: 22672..22917 (246 bp)
Type: Others
Protein ID: WP_004420603.1
Location: 24315..24656 (342 bp)
Type: Toxin
Protein ID: WP_000240418.1
Location: 24650..24886 (237 bp)
Type: Antitoxin
Protein ID: WP_000443825.1
Location: 25200..26411 (1212 bp)
Type: Others
Protein ID: WP_061233587.1
Location: 26652..27074 (423 bp)
Type: Others
Protein ID: WP_061233586.1
Location: 27654..28781 (1128 bp)
Type: Others
Protein ID: WP_061233585.1
Location: 28781..29644 (864 bp)
Type: Others
Protein ID: WP_061233588.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MAL07_RS19605 (MAL07_19605)20474..20740+267Protein_14IS5/IS1182 family transposase-
MAL07_RS19610 (MAL07_19610)20886..22005+1120Protein_15hypothetical protein-
MAL07_RS19615 (MAL07_19615)22268..22672-405WP_004420606.1putative toxin-antitoxin system toxin component, PIN family-
MAL07_RS19620 (MAL07_19620)22672..22917-246WP_004420603.1ribbon-helix-helix domain-containing protein-
MAL07_RS19625 (MAL07_19625)23597..23905+309WP_002148401.1hypothetical protein-
MAL07_RS19630 (MAL07_19630)23871..24245+375Protein_19hypothetical protein-
MAL07_RS19635 (MAL07_19635)24315..24656-342WP_000240418.1endoribonuclease MazFToxin
MAL07_RS19640 (MAL07_19640)24650..24886-237WP_000443825.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
MAL07_RS19645 (MAL07_19645)25200..26411-1212WP_061233587.1PD-(D/E)XK nuclease family protein-
MAL07_RS19650 (MAL07_19650)26652..27074-423WP_061233586.1hypothetical protein-
MAL07_RS19655 (MAL07_19655)27143..27523+381WP_235595273.1helix-turn-helix transcriptional regulator-
MAL07_RS19660 (MAL07_19660)27654..28781-1128WP_061233585.1hypothetical protein-
MAL07_RS19665 (MAL07_19665)28781..29644-864WP_061233588.1adenine-specific DNA-methyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..3815338153
-flankIS/Tn--18968..19816848


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin

Antitoxin PemI-like

(1-78)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12918.12 Da        Isoelectric Point: 9.9595

>T235293 WP_000240418.1 NZ_CP091965:c24656-24315 [Leptospira noguchii]
MVKNRNYTPEKGDIVWLNFTPQAGHEQKGRRPALVLSPKEYNSKTGLAIFCPITSKIKGYPFEVLIKSKKIDGVILSDQV
KNLDWTIREAEFIESINKVSLKEVLDNIKLLIF

Download         Length: 342 bp

>T235293 NZ_LR134236:c1874150-1873776 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8728.95 Da        Isoelectric Point: 5.6663

>AT235293 WP_000443825.1 NZ_CP091965:c24886-24650 [Leptospira noguchii]
MESIIQKWGNSLGIRIPKAMATELELNDGSHVELQYEGDKIVIYPMKKASLEDKLSKITKQNLHSEISTGNSIGNEAW

Download         Length: 237 bp

>AT235293 NZ_LR134236:c1874608-1874240 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACCCCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A4D8SL30

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0F6HC33

References