Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 50518..51089 Replicon plasmid p1_L201601331
Accession NZ_CP091964
Organism Leptospira noguchii strain 201601331

Toxin (Protein)


Gene name mazF Uniprot ID Q8F5A3
Locus tag MAL07_RS19460 Protein ID WP_000240418.1
Coordinates 50748..51089 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M6U553
Locus tag MAL07_RS19455 Protein ID WP_000443825.1
Coordinates 50518..50754 (+) Length 79 a.a.

Genomic Context

MAL07_RS19425MAL07_RS19430MAL07_RS19435MAL07_RS19440MAL07_RS19445MAL07_RS19450MAL07_RS19455MAL07_RS19460MAL07_RS20005MAL07_RS19495MAL07_RS19465MAL07_RS19470MAL07_RS19475MAL07_RS19480MAL07_RS19485MAL07_RS19490
Location: 46165..46509 (345 bp)
Type: Others
Protein ID: WP_036026199.1
Location: 46496..47038 (543 bp)
Type: Others
Protein ID: WP_061251579.1
Location: 47066..47215 (150 bp)
Type: Others
Protein ID: WP_155717419.1
Location: 47208..47522 (315 bp)
Type: Others
Protein ID: WP_002149298.1
Location: 47957..49246 (1290 bp)
Type: Others
Protein ID: WP_061251578.1
Location: 49418..50215 (798 bp)
Type: Others
Protein ID: WP_061251577.1
Location: 50518..50754 (237 bp)
Type: Antitoxin
Protein ID: WP_000443825.1
Location: 50748..51089 (342 bp)
Type: Toxin
Protein ID: WP_000240418.1
Location: 52305..52427 (123 bp)
Type: Others
Protein ID: WP_004444280.1
Location: 55121..55363 (243 bp)
Type: Others
Protein ID: WP_004426407.1
Location: 51159..51533 (375 bp)
Type: Others
Protein ID: Protein_37
Location: 51499..51807 (309 bp)
Type: Others
Protein ID: WP_002148401.1
Location: 51987..52269 (283 bp)
Type: Others
Protein ID: Protein_39
Location: 52525..52767 (243 bp)
Type: Others
Protein ID: WP_243825587.1
Location: 52764..53657 (894 bp)
Type: Others
Protein ID: WP_243825597.1
Location: 54292..55149 (858 bp)
Type: Others
Protein ID: WP_243825588.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MAL07_RS19425 (MAL07_19425)46165..46509+345WP_036026199.1hypothetical protein-
MAL07_RS19430 (MAL07_19430)46496..47038+543WP_061251579.1hypothetical protein-
MAL07_RS19435 (MAL07_19435)47066..47215+150WP_155717419.1hypothetical protein-
MAL07_RS19440 (MAL07_19440)47208..47522+315WP_002149298.1hypothetical protein-
MAL07_RS19445 (MAL07_19445)47957..49246+1290WP_061251578.1hypothetical protein-
MAL07_RS19450 (MAL07_19450)49418..50215+798WP_061251577.1TIGR02391 family protein-
MAL07_RS19455 (MAL07_19455)50518..50754+237WP_000443825.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
MAL07_RS19460 (MAL07_19460)50748..51089+342WP_000240418.1endoribonuclease MazFToxin
MAL07_RS19465 (MAL07_19465)51159..51533-375Protein_37hypothetical protein-
MAL07_RS19470 (MAL07_19470)51499..51807-309WP_002148401.1hypothetical protein-
MAL07_RS19475 (MAL07_19475)51987..52269-283Protein_39leucine-rich repeat domain-containing protein-
MAL07_RS2000552305..52427+123WP_004444280.1hypothetical protein-
MAL07_RS19480 (MAL07_19480)52525..52767-243WP_243825587.1hypothetical protein-
MAL07_RS19485 (MAL07_19485)52764..53657-894WP_243825597.1Rpn family recombination-promoting nuclease/putative transposase-
MAL07_RS19490 (MAL07_19490)54292..55149-858WP_243825588.1Rpn family recombination-promoting nuclease/putative transposase-
MAL07_RS19495 (MAL07_19495)55121..55363+243WP_004426407.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..6524565245


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin

Antitoxin PemI-like

(1-78)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12918.12 Da        Isoelectric Point: 9.9595

>T235292 WP_000240418.1 NZ_CP091964:50748-51089 [Leptospira noguchii]
MVKNRNYTPEKGDIVWLNFTPQAGHEQKGRRPALVLSPKEYNSKTGLAIFCPITSKIKGYPFEVLIKSKKIDGVILSDQV
KNLDWTIREAEFIESINKVSLKEVLDNIKLLIF

Download         Length: 342 bp

>T235292 NZ_LR134236:1859131-1859385 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8728.95 Da        Isoelectric Point: 5.6663

>AT235292 WP_000443825.1 NZ_CP091964:50518-50754 [Leptospira noguchii]
MESIIQKWGNSLGIRIPKAMATELELNDGSHVELQYEGDKIVIYPMKKASLEDKLSKITKQNLHSEISTGNSIGNEAW

Download         Length: 237 bp

>AT235292 NZ_LR134236:1858883-1859134 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A4D8SL30

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0F6HC33

References