Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | chpIK/PemK(toxin) |
| Location | 746247..746823 | Replicon | chromosome |
| Accession | NZ_CP091957 | ||
| Organism | Leptospira noguchii strain IP1512017 | ||
Toxin (Protein)
| Gene name | chpK | Uniprot ID | - |
| Locus tag | MAL03_RS03100 | Protein ID | WP_002155521.1 |
| Coordinates | 746247..746588 (-) | Length | 114 a.a. |
Antitoxin (Protein)
| Gene name | chpI | Uniprot ID | M6U786 |
| Locus tag | MAL03_RS03105 | Protein ID | WP_004425715.1 |
| Coordinates | 746575..746823 (-) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MAL03_RS03085 (MAL03_03085) | 741256..741591 | - | 336 | WP_141598265.1 | VOC family protein | - |
| MAL03_RS03090 (MAL03_03090) | 741588..741866 | - | 279 | WP_002155541.1 | GNAT family N-acetyltransferase | - |
| MAL03_RS03095 (MAL03_03095) | 742748..744622 | + | 1875 | WP_141598266.1 | ATP-dependent DNA helicase RecQ | - |
| MAL03_RS03100 (MAL03_03100) | 746247..746588 | - | 342 | WP_002155521.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| MAL03_RS03105 (MAL03_03105) | 746575..746823 | - | 249 | WP_004425715.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
| MAL03_RS03110 (MAL03_03110) | 747091..747363 | - | 273 | WP_135686010.1 | BrnA antitoxin family protein | - |
| MAL03_RS03115 (MAL03_03115) | 747350..747649 | - | 300 | WP_141598267.1 | BrnT family toxin | - |
| MAL03_RS03120 (MAL03_03120) | 747974..748364 | - | 391 | Protein_623 | type II toxin-antitoxin system VapC family toxin | - |
| MAL03_RS03125 (MAL03_03125) | 748364..748594 | - | 231 | WP_002998826.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| MAL03_RS03130 (MAL03_03130) | 748868..749224 | - | 357 | WP_141598270.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| MAL03_RS03135 (MAL03_03135) | 749221..749481 | - | 261 | WP_002178286.1 | type II toxin-antitoxin system HicA family toxin | - |
| MAL03_RS03140 (MAL03_03140) | 749747..750136 | - | 390 | WP_141598271.1 | type II toxin-antitoxin system MqsA family antitoxin | - |
| MAL03_RS03145 (MAL03_03145) | 750133..750444 | - | 312 | WP_141598272.1 | type II toxin-antitoxin system MqsR family toxin | - |
| MAL03_RS03150 (MAL03_03150) | 750738..751742 | - | 1005 | WP_141598273.1 | DUF2971 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12329.22 Da Isoelectric Point: 9.8437
>T235288 WP_002155521.1 NZ_CP091957:c746588-746247 [Leptospira noguchii]
MIRGEIWWVDLGIPFGSEPGFKRPVLIIQDDSFNQSSISTVVSIAITSNLNLSEAPGNVLISKKESSLSKDSVVNVSQIV
TLDKERFIKRAGKLKSSKINEVETGLKLVTGLN
MIRGEIWWVDLGIPFGSEPGFKRPVLIIQDDSFNQSSISTVVSIAITSNLNLSEAPGNVLISKKESSLSKDSVVNVSQIV
TLDKERFIKRAGKLKSSKINEVETGLKLVTGLN
Download Length: 342 bp
>T235288 NZ_LR134236:859354-859761 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9337.83 Da Isoelectric Point: 10.3019
>AT235288 WP_004425715.1 NZ_CP091957:c746823-746575 [Leptospira noguchii]
MKTAISIPDELFKTAEKIAKKLGIPRSQLFAKALEEFIQSHSKESITEKLNKVYSNKSKELKSNIVDLSVESLRKSLKND
SW
MKTAISIPDELFKTAEKIAKKLGIPRSQLFAKALEEFIQSHSKESITEKLNKVYSNKSKELKSNIVDLSVESLRKSLKND
SW
Download Length: 249 bp
>AT235288 NZ_LR134236:859107-859373 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|