Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpIK/PemK(toxin)
Location 746247..746823 Replicon chromosome
Accession NZ_CP091957
Organism Leptospira noguchii strain IP1512017

Toxin (Protein)


Gene name chpK Uniprot ID -
Locus tag MAL03_RS03100 Protein ID WP_002155521.1
Coordinates 746247..746588 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name chpI Uniprot ID M6U786
Locus tag MAL03_RS03105 Protein ID WP_004425715.1
Coordinates 746575..746823 (-) Length 83 a.a.

Genomic Context

MAL03_RS03095MAL03_RS03085MAL03_RS03090MAL03_RS03100MAL03_RS03105MAL03_RS03110MAL03_RS03115MAL03_RS03120MAL03_RS03125MAL03_RS03130MAL03_RS03135MAL03_RS03140MAL03_RS03145MAL03_RS03150
Location: 742748..744622 (1875 bp)
Type: Others
Protein ID: WP_141598266.1
Location: 741256..741591 (336 bp)
Type: Others
Protein ID: WP_141598265.1
Location: 741588..741866 (279 bp)
Type: Others
Protein ID: WP_002155541.1
Location: 746247..746588 (342 bp)
Type: Toxin
Protein ID: WP_002155521.1
Location: 746575..746823 (249 bp)
Type: Antitoxin
Protein ID: WP_004425715.1
Location: 747091..747363 (273 bp)
Type: Others
Protein ID: WP_135686010.1
Location: 747350..747649 (300 bp)
Type: Others
Protein ID: WP_141598267.1
Location: 747974..748364 (391 bp)
Type: Others
Protein ID: Protein_623
Location: 748364..748594 (231 bp)
Type: Others
Protein ID: WP_002998826.1
Location: 748868..749224 (357 bp)
Type: Others
Protein ID: WP_141598270.1
Location: 749221..749481 (261 bp)
Type: Others
Protein ID: WP_002178286.1
Location: 749747..750136 (390 bp)
Type: Others
Protein ID: WP_141598271.1
Location: 750133..750444 (312 bp)
Type: Others
Protein ID: WP_141598272.1
Location: 750738..751742 (1005 bp)
Type: Others
Protein ID: WP_141598273.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MAL03_RS03085 (MAL03_03085)741256..741591-336WP_141598265.1VOC family protein-
MAL03_RS03090 (MAL03_03090)741588..741866-279WP_002155541.1GNAT family N-acetyltransferase-
MAL03_RS03095 (MAL03_03095)742748..744622+1875WP_141598266.1ATP-dependent DNA helicase RecQ-
MAL03_RS03100 (MAL03_03100)746247..746588-342WP_002155521.1type II toxin-antitoxin system PemK/MazF family toxinToxin
MAL03_RS03105 (MAL03_03105)746575..746823-249WP_004425715.1ribbon-helix-helix domain-containing proteinAntitoxin
MAL03_RS03110 (MAL03_03110)747091..747363-273WP_135686010.1BrnA antitoxin family protein-
MAL03_RS03115 (MAL03_03115)747350..747649-300WP_141598267.1BrnT family toxin-
MAL03_RS03120 (MAL03_03120)747974..748364-391Protein_623type II toxin-antitoxin system VapC family toxin-
MAL03_RS03125 (MAL03_03125)748364..748594-231WP_002998826.1AbrB/MazE/SpoVT family DNA-binding domain-containing protein-
MAL03_RS03130 (MAL03_03130)748868..749224-357WP_141598270.1type II toxin-antitoxin system HicB family antitoxin-
MAL03_RS03135 (MAL03_03135)749221..749481-261WP_002178286.1type II toxin-antitoxin system HicA family toxin-
MAL03_RS03140 (MAL03_03140)749747..750136-390WP_141598271.1type II toxin-antitoxin system MqsA family antitoxin-
MAL03_RS03145 (MAL03_03145)750133..750444-312WP_141598272.1type II toxin-antitoxin system MqsR family toxin-
MAL03_RS03150 (MAL03_03150)750738..751742-1005WP_141598273.1DUF2971 domain-containing protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(2-41)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12329.22 Da        Isoelectric Point: 9.8437

>T235288 WP_002155521.1 NZ_CP091957:c746588-746247 [Leptospira noguchii]
MIRGEIWWVDLGIPFGSEPGFKRPVLIIQDDSFNQSSISTVVSIAITSNLNLSEAPGNVLISKKESSLSKDSVVNVSQIV
TLDKERFIKRAGKLKSSKINEVETGLKLVTGLN

Download         Length: 342 bp

>T235288 NZ_LR134236:859354-859761 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9337.83 Da        Isoelectric Point: 10.3019

>AT235288 WP_004425715.1 NZ_CP091957:c746823-746575 [Leptospira noguchii]
MKTAISIPDELFKTAEKIAKKLGIPRSQLFAKALEEFIQSHSKESITEKLNKVYSNKSKELKSNIVDLSVESLRKSLKND
SW

Download         Length: 249 bp

>AT235288 NZ_LR134236:859107-859373 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
No matching records found

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBM6U786

References