Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 3053550..3054121 Replicon chromosome
Accession NZ_CP091953
Organism Leptospira noguchii strain IP1605021

Toxin (Protein)


Gene name mazF Uniprot ID Q8F5A3
Locus tag MAL09_RS13585 Protein ID WP_000240418.1
Coordinates 3053780..3054121 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M6U553
Locus tag MAL09_RS13580 Protein ID WP_000443825.1
Coordinates 3053550..3053786 (+) Length 79 a.a.

Genomic Context

MAL09_RS13550MAL09_RS13555MAL09_RS13560MAL09_RS13565MAL09_RS13580MAL09_RS13585MAL09_RS13590MAL09_RS13595MAL09_RS13600MAL09_RS13605MAL09_RS13570MAL09_RS13575MAL09_RS13610
Location: 3049222..3050077 (856 bp)
Type: Others
Protein ID: Protein_2731
Location: 3050132..3051279 (1148 bp)
Type: Others
Protein ID: WP_243807739.1
Location: 3051534..3052208 (675 bp)
Type: Others
Protein ID: WP_141599490.1
Location: 3052461..3052658 (198 bp)
Type: Others
Protein ID: WP_181757029.1
Location: 3053550..3053786 (237 bp)
Type: Antitoxin
Protein ID: WP_000443825.1
Location: 3053780..3054121 (342 bp)
Type: Toxin
Protein ID: WP_000240418.1
Location: 3054468..3054733 (266 bp)
Type: Others
Protein ID: Protein_2739
Location: 3054865..3055137 (273 bp)
Type: Others
Protein ID: Protein_2740
Location: 3055667..3056229 (563 bp)
Type: Others
Protein ID: Protein_2741
Location: 3056309..3056494 (186 bp)
Type: Others
Protein ID: WP_141599671.1
Location: 3052720..3053112 (393 bp)
Type: Others
Protein ID: WP_004419230.1
Location: 3053113..3053451 (339 bp)
Type: Others
Protein ID: WP_243807197.1
Location: 3056665..3057534 (870 bp)
Type: Others
Protein ID: WP_243807198.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MAL09_RS13550 (MAL09_13550)3049222..3050077+856Protein_2731IS982 family transposase-
MAL09_RS13555 (MAL09_13555)3050132..3051279+1148WP_243807739.1IS3 family transposase-
MAL09_RS13560 (MAL09_13560)3051534..3052208+675WP_141599490.1hypothetical protein-
MAL09_RS13565 (MAL09_13565)3052461..3052658+198WP_181757029.1hypothetical protein-
MAL09_RS13570 (MAL09_13570)3052720..3053112-393WP_004419230.1transcriptional regulator-
MAL09_RS13575 (MAL09_13575)3053113..3053451-339WP_243807197.1type II toxin-antitoxin system HigB family toxin-
MAL09_RS13580 (MAL09_13580)3053550..3053786+237WP_000443825.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
MAL09_RS13585 (MAL09_13585)3053780..3054121+342WP_000240418.1endoribonuclease MazFToxin
MAL09_RS13590 (MAL09_13590)3054468..3054733+266Protein_2739IS5/IS1182 family transposase-
MAL09_RS13595 (MAL09_13595)3054865..3055137+273Protein_2740IS5/IS1182 family transposase-
MAL09_RS13600 (MAL09_13600)3055667..3056229+563Protein_2741IS5/IS1182 family transposase-
MAL09_RS13605 (MAL09_13605)3056309..3056494+186WP_141599671.1hypothetical protein-
MAL09_RS13610 (MAL09_13610)3056665..3057534-870WP_243807198.1Rpn family recombination-promoting nuclease/putative transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin

Antitoxin PemI-like

(1-78)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12918.12 Da        Isoelectric Point: 9.9595

>T235286 WP_000240418.1 NZ_CP091953:3053780-3054121 [Leptospira noguchii]
MVKNRNYTPEKGDIVWLNFTPQAGHEQKGRRPALVLSPKEYNSKTGLAIFCPITSKIKGYPFEVLIKSKKIDGVILSDQV
KNLDWTIREAEFIESINKVSLKEVLDNIKLLIF

Download         Length: 342 bp

>T235286 NZ_LR134236:653820-654134 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTAGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8728.95 Da        Isoelectric Point: 5.6663

>AT235286 WP_000443825.1 NZ_CP091953:3053550-3053786 [Leptospira noguchii]
MESIIQKWGNSLGIRIPKAMATELELNDGSHVELQYEGDKIVIYPMKKASLEDKLSKITKQNLHSEISTGNSIGNEAW

Download         Length: 237 bp

>AT235286 NZ_LR134236:654131-654547 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCGGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGCTCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A4D8SL30

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0F6HC33

References