Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 753087..753700 Replicon chromosome
Accession NZ_CP091953
Organism Leptospira noguchii strain IP1605021

Toxin (Protein)


Gene name hicA Uniprot ID T0FDD9
Locus tag MAL09_RS03300 Protein ID WP_002178286.1
Coordinates 753440..753700 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag MAL09_RS03295 Protein ID WP_141598270.1
Coordinates 753087..753443 (-) Length 119 a.a.

Genomic Context

MAL09_RS22295MAL09_RS03325MAL09_RS03330MAL09_RS03265MAL09_RS03270MAL09_RS03275MAL09_RS03280MAL09_RS03285MAL09_RS03290MAL09_RS03295MAL09_RS03300MAL09_RS03305MAL09_RS03310MAL09_RS03315MAL09_RS03320
Location: 756302..756424 (123 bp)
Type: Others
Protein ID: WP_016559266.1
Location: 757008..757265 (258 bp)
Type: Others
Protein ID: Protein_668
Location: 757537..758373 (837 bp)
Type: Others
Protein ID: WP_141598588.1
Location: 750469..750810 (342 bp)
Type: Others
Protein ID: WP_002155521.1
Location: 750797..751045 (249 bp)
Type: Others
Protein ID: WP_004425715.1
Location: 751299..751571 (273 bp)
Type: Others
Protein ID: WP_135686010.1
Location: 751558..751857 (300 bp)
Type: Others
Protein ID: WP_141598267.1
Location: 752182..752583 (402 bp)
Type: Others
Protein ID: WP_141598268.1
Location: 752583..752813 (231 bp)
Type: Others
Protein ID: WP_002998826.1
Location: 753087..753443 (357 bp)
Type: Antitoxin
Protein ID: WP_141598270.1
Location: 753440..753700 (261 bp)
Type: Toxin
Protein ID: WP_002178286.1
Location: 753966..754355 (390 bp)
Type: Others
Protein ID: WP_141598271.1
Location: 754352..754663 (312 bp)
Type: Others
Protein ID: WP_141598272.1
Location: 754957..755961 (1005 bp)
Type: Others
Protein ID: WP_141598273.1
Location: 756436..756849 (414 bp)
Type: Others
Protein ID: WP_141598587.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MAL09_RS03265 (MAL09_03265)750469..750810-342WP_002155521.1type II toxin-antitoxin system PemK/MazF family toxin-
MAL09_RS03270 (MAL09_03270)750797..751045-249WP_004425715.1ribbon-helix-helix domain-containing protein-
MAL09_RS03275 (MAL09_03275)751299..751571-273WP_135686010.1BrnA antitoxin family protein-
MAL09_RS03280 (MAL09_03280)751558..751857-300WP_141598267.1BrnT family toxin-
MAL09_RS03285 (MAL09_03285)752182..752583-402WP_141598268.1type II toxin-antitoxin system VapC family toxin-
MAL09_RS03290 (MAL09_03290)752583..752813-231WP_002998826.1AbrB/MazE/SpoVT family DNA-binding domain-containing protein-
MAL09_RS03295 (MAL09_03295)753087..753443-357WP_141598270.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
MAL09_RS03300 (MAL09_03300)753440..753700-261WP_002178286.1type II toxin-antitoxin system HicA family toxinToxin
MAL09_RS03305 (MAL09_03305)753966..754355-390WP_141598271.1type II toxin-antitoxin system MqsA family antitoxin-
MAL09_RS03310 (MAL09_03310)754352..754663-312WP_141598272.1type II toxin-antitoxin system MqsR family toxin-
MAL09_RS03315 (MAL09_03315)754957..755961-1005WP_141598273.1DUF2971 domain-containing protein-
MAL09_RS22295756302..756424+123WP_016559266.1hypothetical protein-
MAL09_RS03320 (MAL09_03320)756436..756849-414WP_141598587.1helix-turn-helix transcriptional regulator-
MAL09_RS03325 (MAL09_03325)757008..757265+258Protein_668helix-turn-helix transcriptional regulator-
MAL09_RS03330 (MAL09_03330)757537..758373+837WP_141598588.1patatin-like phospholipase family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-78)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10032.49 Da        Isoelectric Point: 10.2818

>T235285 WP_002178286.1 NZ_CP091953:c753700-753440 [Leptospira noguchii]
VSKSEKLIQRFLGRPKDFSYDELRKLFSGFGYIEDNSGKSSGSRVAWIHSETKHIIRLHKPHPKNILKSYQINQILDELK
SEGYIK

Download         Length: 261 bp

>T235285 NZ_LR134236:c604771-604307 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 13610.59 Da        Isoelectric Point: 7.2781

>AT235285 WP_141598270.1 NZ_CP091953:c753443-753087 [Leptospira noguchii]
MKDIIEYNGFLGSVHFDADDEVFFGKIEGIEDLVSFEGESVKQLKKAFQESVDDYLILCKKAKKSPEKSFKGSFNVRIPT
ELHRRVYRKSLREGISLNQLVQRALEKEITELKTPHFG

Download         Length: 357 bp

>AT235285 NZ_LR134236:c605106-604771 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBT0FDD9

Antitoxin

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Source
ID
Structure
No matching records found

References