Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA(toxin) |
| Location | 753087..753700 | Replicon | chromosome |
| Accession | NZ_CP091953 | ||
| Organism | Leptospira noguchii strain IP1605021 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | T0FDD9 |
| Locus tag | MAL09_RS03300 | Protein ID | WP_002178286.1 |
| Coordinates | 753440..753700 (-) | Length | 87 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | MAL09_RS03295 | Protein ID | WP_141598270.1 |
| Coordinates | 753087..753443 (-) | Length | 119 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MAL09_RS03265 (MAL09_03265) | 750469..750810 | - | 342 | WP_002155521.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| MAL09_RS03270 (MAL09_03270) | 750797..751045 | - | 249 | WP_004425715.1 | ribbon-helix-helix domain-containing protein | - |
| MAL09_RS03275 (MAL09_03275) | 751299..751571 | - | 273 | WP_135686010.1 | BrnA antitoxin family protein | - |
| MAL09_RS03280 (MAL09_03280) | 751558..751857 | - | 300 | WP_141598267.1 | BrnT family toxin | - |
| MAL09_RS03285 (MAL09_03285) | 752182..752583 | - | 402 | WP_141598268.1 | type II toxin-antitoxin system VapC family toxin | - |
| MAL09_RS03290 (MAL09_03290) | 752583..752813 | - | 231 | WP_002998826.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| MAL09_RS03295 (MAL09_03295) | 753087..753443 | - | 357 | WP_141598270.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| MAL09_RS03300 (MAL09_03300) | 753440..753700 | - | 261 | WP_002178286.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| MAL09_RS03305 (MAL09_03305) | 753966..754355 | - | 390 | WP_141598271.1 | type II toxin-antitoxin system MqsA family antitoxin | - |
| MAL09_RS03310 (MAL09_03310) | 754352..754663 | - | 312 | WP_141598272.1 | type II toxin-antitoxin system MqsR family toxin | - |
| MAL09_RS03315 (MAL09_03315) | 754957..755961 | - | 1005 | WP_141598273.1 | DUF2971 domain-containing protein | - |
| MAL09_RS22295 | 756302..756424 | + | 123 | WP_016559266.1 | hypothetical protein | - |
| MAL09_RS03320 (MAL09_03320) | 756436..756849 | - | 414 | WP_141598587.1 | helix-turn-helix transcriptional regulator | - |
| MAL09_RS03325 (MAL09_03325) | 757008..757265 | + | 258 | Protein_668 | helix-turn-helix transcriptional regulator | - |
| MAL09_RS03330 (MAL09_03330) | 757537..758373 | + | 837 | WP_141598588.1 | patatin-like phospholipase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 87 a.a. Molecular weight: 10032.49 Da Isoelectric Point: 10.2818
>T235285 WP_002178286.1 NZ_CP091953:c753700-753440 [Leptospira noguchii]
VSKSEKLIQRFLGRPKDFSYDELRKLFSGFGYIEDNSGKSSGSRVAWIHSETKHIIRLHKPHPKNILKSYQINQILDELK
SEGYIK
VSKSEKLIQRFLGRPKDFSYDELRKLFSGFGYIEDNSGKSSGSRVAWIHSETKHIIRLHKPHPKNILKSYQINQILDELK
SEGYIK
Download Length: 261 bp
>T235285 NZ_LR134236:c604771-604307 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
Antitoxin
Download Length: 119 a.a. Molecular weight: 13610.59 Da Isoelectric Point: 7.2781
>AT235285 WP_141598270.1 NZ_CP091953:c753443-753087 [Leptospira noguchii]
MKDIIEYNGFLGSVHFDADDEVFFGKIEGIEDLVSFEGESVKQLKKAFQESVDDYLILCKKAKKSPEKSFKGSFNVRIPT
ELHRRVYRKSLREGISLNQLVQRALEKEITELKTPHFG
MKDIIEYNGFLGSVHFDADDEVFFGKIEGIEDLVSFEGESVKQLKKAFQESVDDYLILCKKAKKSPEKSFKGSFNVRIPT
ELHRRVYRKSLREGISLNQLVQRALEKEITELKTPHFG
Download Length: 357 bp
>AT235285 NZ_LR134236:c605106-604771 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|