Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 752182..752813 Replicon chromosome
Accession NZ_CP091953
Organism Leptospira noguchii strain IP1605021

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MAL09_RS03285 Protein ID WP_141598268.1
Coordinates 752182..752583 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID N1WMP3
Locus tag MAL09_RS03290 Protein ID WP_002998826.1
Coordinates 752583..752813 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MAL09_RS03265 (MAL09_03265) 750469..750810 - 342 WP_002155521.1 type II toxin-antitoxin system PemK/MazF family toxin -
MAL09_RS03270 (MAL09_03270) 750797..751045 - 249 WP_004425715.1 ribbon-helix-helix domain-containing protein -
MAL09_RS03275 (MAL09_03275) 751299..751571 - 273 WP_135686010.1 BrnA antitoxin family protein -
MAL09_RS03280 (MAL09_03280) 751558..751857 - 300 WP_141598267.1 BrnT family toxin -
MAL09_RS03285 (MAL09_03285) 752182..752583 - 402 WP_141598268.1 type II toxin-antitoxin system VapC family toxin Toxin
MAL09_RS03290 (MAL09_03290) 752583..752813 - 231 WP_002998826.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
MAL09_RS03295 (MAL09_03295) 753087..753443 - 357 WP_141598270.1 type II toxin-antitoxin system HicB family antitoxin -
MAL09_RS03300 (MAL09_03300) 753440..753700 - 261 WP_002178286.1 type II toxin-antitoxin system HicA family toxin -
MAL09_RS03305 (MAL09_03305) 753966..754355 - 390 WP_141598271.1 type II toxin-antitoxin system MqsA family antitoxin -
MAL09_RS03310 (MAL09_03310) 754352..754663 - 312 WP_141598272.1 type II toxin-antitoxin system MqsR family toxin -
MAL09_RS03315 (MAL09_03315) 754957..755961 - 1005 WP_141598273.1 DUF2971 domain-containing protein -
MAL09_RS22295 756302..756424 + 123 WP_016559266.1 hypothetical protein -
MAL09_RS03320 (MAL09_03320) 756436..756849 - 414 WP_141598587.1 helix-turn-helix transcriptional regulator -
MAL09_RS03325 (MAL09_03325) 757008..757265 + 258 Protein_668 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15214.82 Da        Isoelectric Point: 9.4565

>T235284 WP_141598268.1 NZ_CP091953:c752583-752182 [Leptospira noguchii]
MYLLDTNICIFLIKKKNTALLENLKKKLNKGLFVSSLTVAELEFGIQKSEFKEKNKISLIEFLSIFNIISFTDKDAESYG
IIRAELEKRGNVIGSIDMLLAAQAISNNFIFVTNNTKEFKRIKELKLEDWTAS

Download         Length: 402 bp

>T235284 NZ_LR134236:184703-184810 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8585.80 Da        Isoelectric Point: 8.6850

>AT235284 WP_002998826.1 NZ_CP091953:c752813-752583 [Leptospira noguchii]
MQTAKLFTNGRSQAVRLPKEFQFSGDDVLIQKVGEAVILVPKNKAWNVFLDGLNGFSDDFMEAGREQPKSDKREKL

Download         Length: 231 bp

>AT235284 NZ_LR134236:c184655-184589 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB N1WMP3

References