Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpIK/PemK(toxin)
Location 750469..751045 Replicon chromosome
Accession NZ_CP091953
Organism Leptospira noguchii strain IP1605021

Toxin (Protein)


Gene name chpK Uniprot ID -
Locus tag MAL09_RS03265 Protein ID WP_002155521.1
Coordinates 750469..750810 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name chpI Uniprot ID M6U786
Locus tag MAL09_RS03270 Protein ID WP_004425715.1
Coordinates 750797..751045 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MAL09_RS03250 (MAL09_03250) 745478..745813 - 336 WP_141598265.1 VOC family protein -
MAL09_RS03255 (MAL09_03255) 745810..746088 - 279 WP_002155541.1 GNAT family N-acetyltransferase -
MAL09_RS22290 746490..746615 - 126 WP_279577842.1 hypothetical protein -
MAL09_RS03260 (MAL09_03260) 746970..748844 + 1875 WP_141598266.1 ATP-dependent DNA helicase RecQ -
MAL09_RS03265 (MAL09_03265) 750469..750810 - 342 WP_002155521.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MAL09_RS03270 (MAL09_03270) 750797..751045 - 249 WP_004425715.1 ribbon-helix-helix domain-containing protein Antitoxin
MAL09_RS03275 (MAL09_03275) 751299..751571 - 273 WP_135686010.1 BrnA antitoxin family protein -
MAL09_RS03280 (MAL09_03280) 751558..751857 - 300 WP_141598267.1 BrnT family toxin -
MAL09_RS03285 (MAL09_03285) 752182..752583 - 402 WP_141598268.1 type II toxin-antitoxin system VapC family toxin -
MAL09_RS03290 (MAL09_03290) 752583..752813 - 231 WP_002998826.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
MAL09_RS03295 (MAL09_03295) 753087..753443 - 357 WP_141598270.1 type II toxin-antitoxin system HicB family antitoxin -
MAL09_RS03300 (MAL09_03300) 753440..753700 - 261 WP_002178286.1 type II toxin-antitoxin system HicA family toxin -
MAL09_RS03305 (MAL09_03305) 753966..754355 - 390 WP_141598271.1 type II toxin-antitoxin system MqsA family antitoxin -
MAL09_RS03310 (MAL09_03310) 754352..754663 - 312 WP_141598272.1 type II toxin-antitoxin system MqsR family toxin -
MAL09_RS03315 (MAL09_03315) 754957..755961 - 1005 WP_141598273.1 DUF2971 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(2-41)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12329.22 Da        Isoelectric Point: 9.8437

>T235283 WP_002155521.1 NZ_CP091953:c750810-750469 [Leptospira noguchii]
MIRGEIWWVDLGIPFGSEPGFKRPVLIIQDDSFNQSSISTVVSIAITSNLNLSEAPGNVLISKKESSLSKDSVVNVSQIV
TLDKERFIKRAGKLKSSKINEVETGLKLVTGLN

Download         Length: 342 bp

>T235283 NZ_LR134236:184220-184327 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9337.83 Da        Isoelectric Point: 10.3019

>AT235283 WP_004425715.1 NZ_CP091953:c751045-750797 [Leptospira noguchii]
MKTAISIPDELFKTAEKIAKKLGIPRSQLFAKALEEFIQSHSKESITEKLNKVYSNKSKELKSNIVDLSVESLRKSLKND
SW

Download         Length: 249 bp

>AT235283 NZ_LR134236:c184163-184106 [Escherichia coli]
TCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB M6U786

References