Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpIK/PemK(toxin)
Location 750469..751045 Replicon chromosome
Accession NZ_CP091953
Organism Leptospira noguchii strain IP1605021

Toxin (Protein)


Gene name chpK Uniprot ID -
Locus tag MAL09_RS03265 Protein ID WP_002155521.1
Coordinates 750469..750810 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name chpI Uniprot ID M6U786
Locus tag MAL09_RS03270 Protein ID WP_004425715.1
Coordinates 750797..751045 (-) Length 83 a.a.

Genomic Context

MAL09_RS03260MAL09_RS03250MAL09_RS03255MAL09_RS22290MAL09_RS03265MAL09_RS03270MAL09_RS03275MAL09_RS03280MAL09_RS03285MAL09_RS03290MAL09_RS03295MAL09_RS03300MAL09_RS03305MAL09_RS03310MAL09_RS03315
Location: 746970..748844 (1875 bp)
Type: Others
Protein ID: WP_141598266.1
Location: 745478..745813 (336 bp)
Type: Others
Protein ID: WP_141598265.1
Location: 745810..746088 (279 bp)
Type: Others
Protein ID: WP_002155541.1
Location: 746490..746615 (126 bp)
Type: Others
Protein ID: WP_279577842.1
Location: 750469..750810 (342 bp)
Type: Toxin
Protein ID: WP_002155521.1
Location: 750797..751045 (249 bp)
Type: Antitoxin
Protein ID: WP_004425715.1
Location: 751299..751571 (273 bp)
Type: Others
Protein ID: WP_135686010.1
Location: 751558..751857 (300 bp)
Type: Others
Protein ID: WP_141598267.1
Location: 752182..752583 (402 bp)
Type: Others
Protein ID: WP_141598268.1
Location: 752583..752813 (231 bp)
Type: Others
Protein ID: WP_002998826.1
Location: 753087..753443 (357 bp)
Type: Others
Protein ID: WP_141598270.1
Location: 753440..753700 (261 bp)
Type: Others
Protein ID: WP_002178286.1
Location: 753966..754355 (390 bp)
Type: Others
Protein ID: WP_141598271.1
Location: 754352..754663 (312 bp)
Type: Others
Protein ID: WP_141598272.1
Location: 754957..755961 (1005 bp)
Type: Others
Protein ID: WP_141598273.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MAL09_RS03250 (MAL09_03250)745478..745813-336WP_141598265.1VOC family protein-
MAL09_RS03255 (MAL09_03255)745810..746088-279WP_002155541.1GNAT family N-acetyltransferase-
MAL09_RS22290746490..746615-126WP_279577842.1hypothetical protein-
MAL09_RS03260 (MAL09_03260)746970..748844+1875WP_141598266.1ATP-dependent DNA helicase RecQ-
MAL09_RS03265 (MAL09_03265)750469..750810-342WP_002155521.1type II toxin-antitoxin system PemK/MazF family toxinToxin
MAL09_RS03270 (MAL09_03270)750797..751045-249WP_004425715.1ribbon-helix-helix domain-containing proteinAntitoxin
MAL09_RS03275 (MAL09_03275)751299..751571-273WP_135686010.1BrnA antitoxin family protein-
MAL09_RS03280 (MAL09_03280)751558..751857-300WP_141598267.1BrnT family toxin-
MAL09_RS03285 (MAL09_03285)752182..752583-402WP_141598268.1type II toxin-antitoxin system VapC family toxin-
MAL09_RS03290 (MAL09_03290)752583..752813-231WP_002998826.1AbrB/MazE/SpoVT family DNA-binding domain-containing protein-
MAL09_RS03295 (MAL09_03295)753087..753443-357WP_141598270.1type II toxin-antitoxin system HicB family antitoxin-
MAL09_RS03300 (MAL09_03300)753440..753700-261WP_002178286.1type II toxin-antitoxin system HicA family toxin-
MAL09_RS03305 (MAL09_03305)753966..754355-390WP_141598271.1type II toxin-antitoxin system MqsA family antitoxin-
MAL09_RS03310 (MAL09_03310)754352..754663-312WP_141598272.1type II toxin-antitoxin system MqsR family toxin-
MAL09_RS03315 (MAL09_03315)754957..755961-1005WP_141598273.1DUF2971 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(2-41)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12329.22 Da        Isoelectric Point: 9.8437

>T235283 WP_002155521.1 NZ_CP091953:c750810-750469 [Leptospira noguchii]
MIRGEIWWVDLGIPFGSEPGFKRPVLIIQDDSFNQSSISTVVSIAITSNLNLSEAPGNVLISKKESSLSKDSVVNVSQIV
TLDKERFIKRAGKLKSSKINEVETGLKLVTGLN

Download         Length: 342 bp

>T235283 NZ_LR134236:184220-184327 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9337.83 Da        Isoelectric Point: 10.3019

>AT235283 WP_004425715.1 NZ_CP091953:c751045-750797 [Leptospira noguchii]
MKTAISIPDELFKTAEKIAKKLGIPRSQLFAKALEEFIQSHSKESITEKLNKVYSNKSKELKSNIVDLSVESLRKSLKND
SW

Download         Length: 249 bp

>AT235283 NZ_LR134236:c184163-184106 [Escherichia coli]
TCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBM6U786

References