Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/PRK09907-MazE |
| Location | 45690..46261 | Replicon | plasmid p1_LIP1705032 |
| Accession | NZ_CP091942 | ||
| Organism | Leptospira noguchii strain IP1705032 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | Q8F5A3 |
| Locus tag | MAL05_RS19140 | Protein ID | WP_000240418.1 |
| Coordinates | 45920..46261 (+) | Length | 114 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | M6U553 |
| Locus tag | MAL05_RS19135 | Protein ID | WP_000443825.1 |
| Coordinates | 45690..45926 (+) | Length | 79 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MAL05_RS19320 | 40822..41205 | + | 384 | WP_279577593.1 | Rpn family recombination-promoting nuclease/putative transposase | - |
| MAL05_RS19120 (MAL05_19120) | 41919..43148 | + | 1230 | Protein_28 | group II intron reverse transcriptase/maturase | - |
| MAL05_RS19125 (MAL05_19125) | 44019..44555 | + | 537 | WP_243828123.1 | PD-(D/E)XK nuclease family protein | - |
| MAL05_RS19130 (MAL05_19130) | 44654..45190 | + | 537 | WP_243828124.1 | hypothetical protein | - |
| MAL05_RS19135 (MAL05_19135) | 45690..45926 | + | 237 | WP_000443825.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
| MAL05_RS19140 (MAL05_19140) | 45920..46261 | + | 342 | WP_000240418.1 | endoribonuclease MazF | Toxin |
| MAL05_RS19145 (MAL05_19145) | 46331..46705 | - | 375 | Protein_33 | hypothetical protein | - |
| MAL05_RS19150 (MAL05_19150) | 46671..46979 | - | 309 | WP_002148401.1 | hypothetical protein | - |
| MAL05_RS19155 (MAL05_19155) | 47159..47441 | - | 283 | Protein_35 | leucine-rich repeat domain-containing protein | - |
| MAL05_RS19325 | 47477..47599 | + | 123 | WP_004444280.1 | hypothetical protein | - |
| MAL05_RS19160 (MAL05_19160) | 47697..47939 | - | 243 | WP_243825587.1 | hypothetical protein | - |
| MAL05_RS19165 (MAL05_19165) | 47936..48829 | - | 894 | WP_243828129.1 | Rpn family recombination-promoting nuclease/putative transposase | - |
| MAL05_RS19170 (MAL05_19170) | 49464..50320 | - | 857 | Protein_39 | Rpn family recombination-promoting nuclease/putative transposase | - |
| MAL05_RS19175 (MAL05_19175) | 50292..50534 | + | 243 | WP_243824180.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..58999 | 58999 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12918.12 Da Isoelectric Point: 9.9595
>T235278 WP_000240418.1 NZ_CP091942:45920-46261 [Leptospira noguchii]
MVKNRNYTPEKGDIVWLNFTPQAGHEQKGRRPALVLSPKEYNSKTGLAIFCPITSKIKGYPFEVLIKSKKIDGVILSDQV
KNLDWTIREAEFIESINKVSLKEVLDNIKLLIF
MVKNRNYTPEKGDIVWLNFTPQAGHEQKGRRPALVLSPKEYNSKTGLAIFCPITSKIKGYPFEVLIKSKKIDGVILSDQV
KNLDWTIREAEFIESINKVSLKEVLDNIKLLIF
Download Length: 342 bp
>T235278 NZ_LR134235:3429599-3430009 [Klebsiella variicola]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGTTGGTTCCCTGGCCGCTAAGCTACACCCCGATCTGGCTGCTGCTGTTGTCGCTGGTAGTGTTTGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGAGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTCATCAATAGCGGTATGCTGCTGCGTTTACGCCATGTCGATACCCGGCGCGG
GCAGCATCTGTGGCTGGCGGCGGATAGCATGGATGCCGGAGAATGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGTTGGTTCCCTGGCCGCTAAGCTACACCCCGATCTGGCTGCTGCTGTTGTCGCTGGTAGTGTTTGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGAGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTCATCAATAGCGGTATGCTGCTGCGTTTACGCCATGTCGATACCCGGCGCGG
GCAGCATCTGTGGCTGGCGGCGGATAGCATGGATGCCGGAGAATGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
Antitoxin
Download Length: 79 a.a. Molecular weight: 8728.95 Da Isoelectric Point: 5.6663
>AT235278 WP_000443825.1 NZ_CP091942:45690-45926 [Leptospira noguchii]
MESIIQKWGNSLGIRIPKAMATELELNDGSHVELQYEGDKIVIYPMKKASLEDKLSKITKQNLHSEISTGNSIGNEAW
MESIIQKWGNSLGIRIPKAMATELELNDGSHVELQYEGDKIVIYPMKKASLEDKLSKITKQNLHSEISTGNSIGNEAW
Download Length: 237 bp
>AT235278 NZ_LR134235:3429352-3429618 [Klebsiella variicola]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAACGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAACGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A4D8SL30 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0F6HC33 |