Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpIK/PemK(toxin)
Location 728432..729008 Replicon chromosome
Accession NZ_CP091940
Organism Leptospira noguchii strain IP1705032

Toxin (Protein)


Gene name chpK Uniprot ID -
Locus tag MAL05_RS02855 Protein ID WP_002155521.1
Coordinates 728432..728773 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name chpI Uniprot ID M6U786
Locus tag MAL05_RS02860 Protein ID WP_004425715.1
Coordinates 728760..729008 (-) Length 83 a.a.

Genomic Context

MAL05_RS02850MAL05_RS19215MAL05_RS02845MAL05_RS02855MAL05_RS02860MAL05_RS02865MAL05_RS02870MAL05_RS02875MAL05_RS02880MAL05_RS02885
Location: 724918..726792 (1875 bp)
Type: Others
Protein ID: WP_004425742.1
Location: 727864..727995 (132 bp)
Type: Others
Protein ID: WP_279575168.1
Location: 723763..724041 (279 bp)
Type: Others
Protein ID: WP_002155541.1
Location: 728432..728773 (342 bp)
Type: Toxin
Protein ID: WP_002155521.1
Location: 728760..729008 (249 bp)
Type: Antitoxin
Protein ID: WP_004425715.1
Location: 729276..729548 (273 bp)
Type: Others
Protein ID: WP_004425613.1
Location: 729535..729834 (300 bp)
Type: Others
Protein ID: WP_004425722.1
Location: 730181..730504 (324 bp)
Type: Others
Protein ID: WP_243825533.1
Location: 730786..731367 (582 bp)
Type: Others
Protein ID: WP_232436043.1
Location: 732477..733322 (846 bp)
Type: Others
Protein ID: WP_002155522.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MAL05_RS02845 (MAL05_02845)723763..724041-279WP_002155541.1GNAT family N-acetyltransferase-
MAL05_RS02850 (MAL05_02850)724918..726792+1875WP_004425742.1ATP-dependent DNA helicase RecQ-
MAL05_RS19215727864..727995+132WP_279575168.1hypothetical protein-
MAL05_RS02855 (MAL05_02855)728432..728773-342WP_002155521.1type II toxin-antitoxin system PemK/MazF family toxinToxin
MAL05_RS02860 (MAL05_02860)728760..729008-249WP_004425715.1ribbon-helix-helix domain-containing proteinAntitoxin
MAL05_RS02865 (MAL05_02865)729276..729548-273WP_004425613.1BrnA antitoxin family protein-
MAL05_RS02870 (MAL05_02870)729535..729834-300WP_004425722.1BrnT family toxin-
MAL05_RS02875 (MAL05_02875)730181..730504-324WP_243825533.1hypothetical protein-
MAL05_RS02880 (MAL05_02880)730786..731367-582WP_232436043.1hypothetical protein-
MAL05_RS02885 (MAL05_02885)732477..733322-846WP_002155522.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(2-41)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12329.22 Da        Isoelectric Point: 9.8437

>T235277 WP_002155521.1 NZ_CP091940:c728773-728432 [Leptospira noguchii]
MIRGEIWWVDLGIPFGSEPGFKRPVLIIQDDSFNQSSISTVVSIAITSNLNLSEAPGNVLISKKESSLSKDSVVNVSQIV
TLDKERFIKRAGKLKSSKINEVETGLKLVTGLN

Download         Length: 342 bp

>T235277 NZ_LR134235:2993157-2993504 [Klebsiella variicola]
ATGTGGGATGCAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGGTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9337.83 Da        Isoelectric Point: 10.3019

>AT235277 WP_004425715.1 NZ_CP091940:c729008-728760 [Leptospira noguchii]
MKTAISIPDELFKTAEKIAKKLGIPRSQLFAKALEEFIQSHSKESITEKLNKVYSNKSKELKSNIVDLSVESLRKSLKND
SW

Download         Length: 249 bp

>AT235277 NZ_LR134235:2993504-2993803 [Klebsiella variicola]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGATCCGCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACGTTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBM6U786

References