Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpIK/PemK(toxin)
Location 775967..776543 Replicon chromosome
Accession NZ_CP091936
Organism Leptospira noguchii strain IP1709037

Toxin (Protein)


Gene name chpK Uniprot ID -
Locus tag MAL08_RS03355 Protein ID WP_002155521.1
Coordinates 775967..776308 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name chpI Uniprot ID A0A829BWD5
Locus tag MAL08_RS03360 Protein ID WP_004450848.1
Coordinates 776295..776543 (-) Length 83 a.a.

Genomic Context

MAL08_RS03350MAL08_RS03370MAL08_RS03345MAL08_RS03355MAL08_RS03360MAL08_RS03365MAL08_RS03375MAL08_RS03380MAL08_RS03385MAL08_RS03390MAL08_RS03395
Location: 772235..774109 (1875 bp)
Type: Others
Protein ID: WP_004425742.1
Location: 777363..777620 (258 bp)
Type: Others
Protein ID: Protein_677
Location: 771510..771659 (150 bp)
Type: Others
Protein ID: WP_243818347.1
Location: 775967..776308 (342 bp)
Type: Toxin
Protein ID: WP_002155521.1
Location: 776295..776543 (249 bp)
Type: Antitoxin
Protein ID: WP_004450848.1
Location: 776794..777159 (366 bp)
Type: Others
Protein ID: WP_155243119.1
Location: 778122..778436 (315 bp)
Type: Others
Protein ID: WP_004432609.1
Location: 778481..779428 (948 bp)
Type: Others
Protein ID: WP_243818348.1
Location: 779496..779681 (186 bp)
Type: Others
Protein ID: Protein_680
Location: 779699..780420 (722 bp)
Type: Others
Protein ID: Protein_681
Location: 780420..781307 (888 bp)
Type: Others
Protein ID: WP_243818349.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MAL08_RS03345 (MAL08_03345)771510..771659-150WP_243818347.1hypothetical protein-
MAL08_RS03350 (MAL08_03350)772235..774109+1875WP_004425742.1ATP-dependent DNA helicase RecQ-
MAL08_RS03355 (MAL08_03355)775967..776308-342WP_002155521.1type II toxin-antitoxin system PemK/MazF family toxinToxin
MAL08_RS03360 (MAL08_03360)776295..776543-249WP_004450848.1ribbon-helix-helix domain-containing proteinAntitoxin
MAL08_RS03365 (MAL08_03365)776794..777159-366WP_155243119.1XRE family transcriptional regulator-
MAL08_RS03370 (MAL08_03370)777363..777620+258Protein_677helix-turn-helix transcriptional regulator-
MAL08_RS03375 (MAL08_03375)778122..778436-315WP_004432609.1hypothetical protein-
MAL08_RS03380 (MAL08_03380)778481..779428-948WP_243818348.1phage Gp37/Gp68 family protein-
MAL08_RS03385 (MAL08_03385)779496..779681-186Protein_680hypothetical protein-
MAL08_RS03390 (MAL08_03390)779699..780420-722Protein_681hypothetical protein-
MAL08_RS03395 (MAL08_03395)780420..781307-888WP_243818349.1tail fiber protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--766065..81487948814


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(2-41)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12329.22 Da        Isoelectric Point: 9.8437

>T235276 WP_002155521.1 NZ_CP091936:c776308-775967 [Leptospira noguchii]
MIRGEIWWVDLGIPFGSEPGFKRPVLIIQDDSFNQSSISTVVSIAITSNLNLSEAPGNVLISKKESSLSKDSVVNVSQIV
TLDKERFIKRAGKLKSSKINEVETGLKLVTGLN

Download         Length: 342 bp

>T235276 NZ_LR134235:2966869-2967237 [Klebsiella variicola]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCGGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9308.83 Da        Isoelectric Point: 10.3019

>AT235276 WP_004450848.1 NZ_CP091936:c776543-776295 [Leptospira noguchii]
MKTAISIPDELFKTAEKIAKKLGIPRSQLFAKALEEFIQSHSKESITEKLNKVYSIKSKELKSNIADLSVESLRKSLKND
SW

Download         Length: 249 bp

>AT235276 NZ_LR134235:2966651-2966872 [Klebsiella variicola]
ATGAAAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A829BWD5

References