Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 40260..40831 Replicon plasmid p2_LIP1712055
Accession NZ_CP091931
Organism Leptospira noguchii strain IP1712055

Toxin (Protein)


Gene name mazF Uniprot ID Q8F5A3
Locus tag MAL02_RS19090 Protein ID WP_000240418.1
Coordinates 40490..40831 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M6U553
Locus tag MAL02_RS19085 Protein ID WP_000443825.1
Coordinates 40260..40496 (+) Length 79 a.a.

Genomic Context

MAL02_RS19055MAL02_RS19060MAL02_RS19065MAL02_RS19070MAL02_RS19075MAL02_RS19080MAL02_RS19085MAL02_RS19090MAL02_RS19110MAL02_RS19115MAL02_RS19095MAL02_RS19100MAL02_RS19105MAL02_RS19120MAL02_RS19125
Location: 35909..36253 (345 bp)
Type: Others
Protein ID: WP_036026199.1
Location: 36240..36781 (542 bp)
Type: Others
Protein ID: Protein_20
Location: 36809..36958 (150 bp)
Type: Others
Protein ID: WP_155717419.1
Location: 36951..37265 (315 bp)
Type: Others
Protein ID: WP_002149298.1
Location: 37700..38989 (1290 bp)
Type: Others
Protein ID: WP_061251578.1
Location: 39161..39958 (798 bp)
Type: Others
Protein ID: WP_061251577.1
Location: 40260..40496 (237 bp)
Type: Antitoxin
Protein ID: WP_000443825.1
Location: 40490..40831 (342 bp)
Type: Toxin
Protein ID: WP_000240418.1
Location: 42214..42459 (246 bp)
Type: Others
Protein ID: WP_004420603.1
Location: 42459..42863 (405 bp)
Type: Others
Protein ID: WP_004420606.1
Location: 40901..41270 (370 bp)
Type: Others
Protein ID: Protein_27
Location: 41267..41545 (279 bp)
Type: Others
Protein ID: WP_243824196.1
Location: 41608..41772 (165 bp)
Type: Others
Protein ID: WP_004420657.1
Location: 43126..44246 (1121 bp)
Type: Others
Protein ID: Protein_32
Location: 44387..44658 (272 bp)
Type: Others
Protein ID: Protein_33
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MAL02_RS19055 (MAL02_19055)35909..36253+345WP_036026199.1hypothetical protein-
MAL02_RS19060 (MAL02_19060)36240..36781+542Protein_20hypothetical protein-
MAL02_RS19065 (MAL02_19065)36809..36958+150WP_155717419.1hypothetical protein-
MAL02_RS19070 (MAL02_19070)36951..37265+315WP_002149298.1hypothetical protein-
MAL02_RS19075 (MAL02_19075)37700..38989+1290WP_061251578.1hypothetical protein-
MAL02_RS19080 (MAL02_19080)39161..39958+798WP_061251577.1TIGR02391 family protein-
MAL02_RS19085 (MAL02_19085)40260..40496+237WP_000443825.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
MAL02_RS19090 (MAL02_19090)40490..40831+342WP_000240418.1endoribonuclease MazFToxin
MAL02_RS19095 (MAL02_19095)40901..41270-370Protein_27hypothetical protein-
MAL02_RS19100 (MAL02_19100)41267..41545-279WP_243824196.1hypothetical protein-
MAL02_RS19105 (MAL02_19105)41608..41772-165WP_004420657.1hypothetical protein-
MAL02_RS19110 (MAL02_19110)42214..42459+246WP_004420603.1ribbon-helix-helix domain-containing protein-
MAL02_RS19115 (MAL02_19115)42459..42863+405WP_004420606.1putative toxin-antitoxin system toxin component, PIN family-
MAL02_RS19120 (MAL02_19120)43126..44246-1121Protein_32hypothetical protein-
MAL02_RS19125 (MAL02_19125)44387..44658-272Protein_33IS5/IS1182 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-flankIS/Tn--44410..44658248
-insideNon-Mobilizable plasmid--1..6132261322


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin

Antitoxin PemI-like

(1-78)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12918.12 Da        Isoelectric Point: 9.9595

>T235275 WP_000240418.1 NZ_CP091931:40490-40831 [Leptospira noguchii]
MVKNRNYTPEKGDIVWLNFTPQAGHEQKGRRPALVLSPKEYNSKTGLAIFCPITSKIKGYPFEVLIKSKKIDGVILSDQV
KNLDWTIREAEFIESINKVSLKEVLDNIKLLIF

Download         Length: 342 bp

>T235275 NZ_LR134235:c2567497-2567114 [Klebsiella variicola]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGTACGCGAATGGCGCTAAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTGATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAACTACACCCTGAATAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8728.95 Da        Isoelectric Point: 5.6663

>AT235275 WP_000443825.1 NZ_CP091931:40260-40496 [Leptospira noguchii]
MESIIQKWGNSLGIRIPKAMATELELNDGSHVELQYEGDKIVIYPMKKASLEDKLSKITKQNLHSEISTGNSIGNEAW

Download         Length: 237 bp

>AT235275 NZ_LR134235:c2567739-2567497 [Klebsiella variicola]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A4D8SL30

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0F6HC33

References