Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpIK/PemK(toxin)
Location 735431..736007 Replicon chromosome
Accession NZ_CP091928
Organism Leptospira noguchii strain IP1712055

Toxin (Protein)


Gene name chpK Uniprot ID -
Locus tag MAL02_RS02880 Protein ID WP_002155521.1
Coordinates 735431..735772 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name chpI Uniprot ID M6U786
Locus tag MAL02_RS02885 Protein ID WP_004425715.1
Coordinates 735759..736007 (-) Length 83 a.a.

Genomic Context

MAL02_RS02875MAL02_RS02870MAL02_RS02880MAL02_RS02885MAL02_RS02890MAL02_RS02895MAL02_RS02900MAL02_RS02905MAL02_RS02910MAL02_RS02915
Location: 731909..733783 (1875 bp)
Type: Others
Protein ID: WP_004425742.1
Location: 730750..731028 (279 bp)
Type: Others
Protein ID: WP_002155541.1
Location: 735431..735772 (342 bp)
Type: Toxin
Protein ID: WP_002155521.1
Location: 735759..736007 (249 bp)
Type: Antitoxin
Protein ID: WP_004425715.1
Location: 736373..737041 (669 bp)
Type: Others
Protein ID: Protein_571
Location: 737066..737539 (474 bp)
Type: Others
Protein ID: WP_243823874.1
Location: 737530..737844 (315 bp)
Type: Others
Protein ID: WP_152926911.1
Location: 737864..738076 (213 bp)
Type: Others
Protein ID: WP_053523145.1
Location: 738720..739565 (846 bp)
Type: Others
Protein ID: WP_243820437.1
Location: 739567..740847 (1281 bp)
Type: Others
Protein ID: WP_004437627.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MAL02_RS02870 (MAL02_02870)730750..731028-279WP_002155541.1GNAT family N-acetyltransferase-
MAL02_RS02875 (MAL02_02875)731909..733783+1875WP_004425742.1ATP-dependent DNA helicase RecQ-
MAL02_RS02880 (MAL02_02880)735431..735772-342WP_002155521.1type II toxin-antitoxin system PemK/MazF family toxinToxin
MAL02_RS02885 (MAL02_02885)735759..736007-249WP_004425715.1ribbon-helix-helix domain-containing proteinAntitoxin
MAL02_RS02890 (MAL02_02890)736373..737041-669Protein_571DUF4238 domain-containing protein-
MAL02_RS02895 (MAL02_02895)737066..737539-474WP_243823874.1IS5 family transposase-
MAL02_RS02900 (MAL02_02900)737530..737844-315WP_152926911.1transposase-
MAL02_RS02905 (MAL02_02905)737864..738076-213WP_053523145.1hypothetical protein-
MAL02_RS02910 (MAL02_02910)738720..739565-846WP_243820437.1hypothetical protein-
MAL02_RS02915 (MAL02_02915)739567..740847-1281WP_004437627.1phosphoribosylamine--glycine ligase-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(2-41)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12329.22 Da        Isoelectric Point: 9.8437

>T235274 WP_002155521.1 NZ_CP091928:c735772-735431 [Leptospira noguchii]
MIRGEIWWVDLGIPFGSEPGFKRPVLIIQDDSFNQSSISTVVSIAITSNLNLSEAPGNVLISKKESSLSKDSVVNVSQIV
TLDKERFIKRAGKLKSSKINEVETGLKLVTGLN

Download         Length: 342 bp

>T235274 NZ_LR134235:c2238539-2237622 [Klebsiella variicola]
ATGGATATACAGGCGCCCTATTATCGGCAGGTTGCTCTGTTAATGCAGGTTTTACCCTATGTTGCCGTCGAACGGGAATT
TGCTCTGAAAGGTGGCACGGCAATCAATCTCTTTATCCGTGATTTCCCACGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAACGATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCTAATCTGCAACAACAG
GCAGGTATGAACGCTGTATTACAAGCTAATCGTTCCGATGAGATGCGTGTCGTTGTTACTACCGATAGCGCACAAATAAA
GATAGAGGTCTCACCGGTCGCACGGGGAACATTATATCCACCACAGGAGCGAGAGGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCGGTGGTTTCGTTGCCCGATCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGATGTGAAATTACTTCTTGATGCGCAGGAGCTTAACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTTAGCCATAATCGGCCTCTGGCTGAAGTGCTTAGTCCTCGCTGGAAAGATATTGCTGAACCCTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCTACAGGATGATTGATGCGTTAAAATCC
TGTTTCACGCAACAGGATGTCGATTTTTTGCTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAACGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGTTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9337.83 Da        Isoelectric Point: 10.3019

>AT235274 WP_004425715.1 NZ_CP091928:c736007-735759 [Leptospira noguchii]
MKTAISIPDELFKTAEKIAKKLGIPRSQLFAKALEEFIQSHSKESITEKLNKVYSNKSKELKSNIVDLSVESLRKSLKND
SW

Download         Length: 249 bp

>AT235274 NZ_LR134235:c2239303-2238545 [Klebsiella variicola]
ATGCCATCAAAATTAAACTGGCTGCTGCAAAACAGTGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCGGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACACGCAAAGTGGCTGGTTAAAAAAACGAGGCAACGGCGTATACGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTAGCCGCTCCGGTGTATGTCGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGTCGTTCACACTATCTACAGCTCAAACAAAACCAGTGCTGGTTGAGTATGGAAAATAAAGCGCT
GCTGCCAAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGCAAAAACTGCCGGTGCTGGATGATA
AATACCGCGTAATGCTTGATGTAAAAGGGAAAAGACTCACCGGCAGTGCGCCGGAACTGGCTGCTTACGAGTTGTTGAGC
GCGGTACCGGGGACCCTCTCATTTAACCACGCGGCAGAGCTTTTCCAGGGACTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTGCTTTCTGTCAGCCAGTCCGTGCAGACCAAGCGTTTGTATCTCTTTTTCGCCAGTTTTTACGAGCATGGTTGGC
TCAGACGAATCGATAGCCAAAAAATCGATCTGGGTGCGGGTAAGCGGCAAATCGTGGTAAATGGCAAGTTCAATGCTCAA
TATCAAATCACTGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
No matching records found

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBM6U786

References