Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3674971..3675769 Replicon chromosome
Accession NZ_CP091925
Organism Escherichia coli strain JNQH497

Toxin (Protein)


Gene name yeeV Uniprot ID A0A166U9J9
Locus tag KIF99_RS17960 Protein ID WP_000854695.1
Coordinates 3674971..3675348 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2U2UUE3
Locus tag KIF99_RS17965 Protein ID WP_016243360.1
Coordinates 3675395..3675769 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KIF99_RS17930 (3670760) 3670760..3670885 - 126 Protein_3526 DUF4942 domain-containing protein -
KIF99_RS17935 (3671055) 3671055..3672596 + 1542 WP_001298859.1 IS21-like element ISEc12 family transposase -
KIF99_RS17940 (3672611) 3672611..3673357 + 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
KIF99_RS17945 (3673428) 3673428..3674192 - 765 WP_241071018.1 DUF4942 domain-containing protein -
KIF99_RS17950 (3674277) 3674277..3674474 - 198 WP_000839228.1 DUF957 domain-containing protein -
KIF99_RS17955 (3674486) 3674486..3674974 - 489 WP_000761710.1 DUF5983 family protein -
KIF99_RS17960 (3674971) 3674971..3675348 - 378 WP_000854695.1 TA system toxin CbtA family protein Toxin
KIF99_RS17965 (3675395) 3675395..3675769 - 375 WP_016243360.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KIF99_RS17970 (3675932) 3675932..3676153 - 222 WP_000692307.1 DUF987 domain-containing protein -
KIF99_RS17975 (3676222) 3676222..3676698 - 477 WP_001186773.1 RadC family protein -
KIF99_RS17980 (3676714) 3676714..3677193 - 480 WP_000860084.1 antirestriction protein -
KIF99_RS17985 (3677275) 3677275..3678093 - 819 WP_001241366.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14062.03 Da        Isoelectric Point: 7.7531

>T235266 WP_000854695.1 NZ_CP091925:c3675348-3674971 [Escherichia coli]
MKTLPDTHVREASCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPGAKQ

Download         Length: 378 bp

>T235266 NZ_LR134234:3691123-3691296 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13810.66 Da        Isoelectric Point: 7.0266

>AT235266 WP_016243360.1 NZ_CP091925:c3675769-3675395 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT235266 NZ_LR134234:3690799-3691095 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A166U9J9

Antitoxin

Source ID Structure
AlphaFold DB A0A2U2UUE3

References