Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2279601..2280127 | Replicon | chromosome |
| Accession | NZ_CP091925 | ||
| Organism | Escherichia coli strain JNQH497 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | KIF99_RS11110 | Protein ID | WP_000323025.1 |
| Coordinates | 2279840..2280127 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | KIF99_RS11105 | Protein ID | WP_000534858.1 |
| Coordinates | 2279601..2279840 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KIF99_RS11075 (2274791) | 2274791..2275959 | + | 1169 | WP_094249652.1 | IS3-like element ISEc52 family transposase | - |
| KIF99_RS11080 (2275984) | 2275984..2276351 | + | 368 | Protein_2176 | hypothetical protein | - |
| KIF99_RS11085 (2277007) | 2277007..2278029 | + | 1023 | Protein_2177 | ISNCY family transposase | - |
| KIF99_RS11090 (2278150) | 2278150..2278299 | + | 150 | WP_011443592.1 | protein YdfW | - |
| KIF99_RS11095 (2278736) | 2278736..2279068 | - | 333 | WP_001301033.1 | FlxA-like family protein | - |
| KIF99_RS11100 (2279271) | 2279271..2279576 | - | 306 | WP_001326990.1 | protein YdfV | - |
| KIF99_RS11105 (2279601) | 2279601..2279840 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| KIF99_RS11110 (2279840) | 2279840..2280127 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| KIF99_RS11115 (2280199) | 2280199..2280354 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| KIF99_RS11120 (2280571) | 2280571..2280822 | + | 252 | WP_000980994.1 | protein Rem | - |
| KIF99_RS11125 (2280889) | 2280889..2281167 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| KIF99_RS11130 (2281169) | 2281169..2282218 | + | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| KIF99_RS11135 (2282232) | 2282232..2282984 | + | 753 | WP_001047135.1 | antitermination protein | - |
| KIF99_RS11140 (2283262) | 2283262..2283351 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| KIF99_RS11145 (2283406) | 2283406..2283618 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| KIF99_RS11150 (2283919) | 2283919..2284134 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| KIF99_RS11155 (2284498) | 2284498..2284668 | - | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| KIF99_RS11160 (2284888) | 2284888..2285103 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2264702..2306567 | 41865 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T235262 WP_000323025.1 NZ_CP091925:2279840-2280127 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T235262 NZ_LR134234:c2226904-2226497 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT235262 WP_000534858.1 NZ_CP091925:2279601-2279840 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT235262 NZ_LR134234:c2227151-2226885 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|