Detailed information of TA system TA023526

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 602223..602803
• Replicon: chromosome
• Accession: NC_011989
• Organism: Agrobacterium vitis S4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: B9JRM2
• Locus tag: AVI_RS02825
• Protein ID: WP_015914923.1
• Coordinates: 602223..602606 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: B9JRM3
• Locus tag: AVI_RS02830
• Protein ID: WP_015914924.1
• Coordinates: 602603..602803 (-)
• Length: 67 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AVI_RS29470	598862..599641	-	780	WP_187152371.1	trypsin-like serine protease	-
AVI_RS30440	599955..600236	+	282	WP_139192414.1	hypothetical protein	-
AVI_RS02815	600364..600570	-	207	WP_015914921.1	hypothetical protein	-
AVI_RS29475	600686..601081	+	396	WP_187152372.1	TetR/AcrR family transcriptional regulator C-terminal ligand-binding domain-containing protein	-
AVI_RS30965	601033..601914	+	882	WP_041696194.1	hypothetical protein	-
AVI_RS02825	602223..602606	-	384	WP_015914923.1	type II toxin-antitoxin system VapC family toxin	Toxin
AVI_RS02830	602603..602803	-	201	WP_015914924.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
AVI_RS02835	603058..603726	-	669	WP_139192415.1	hypothetical protein	-
AVI_RS02840	604211..607426	-	3216	WP_015914925.1	metallophosphoesterase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	559226..611859	52633

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-42)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14047.15 Da
• Isoelectric Point: 6.6005

>T23526 WP_015914923.1 NC_011989:c602606-602223 [Agrobacterium vitis S4]
VILVDTSIWIDHFRHGDVELCKIIEDDRLLCHPFVIGELALGSLREREAVIGFLAAQREAAIATHAEVMTVIDRYSIFSM
GIGYTDAHLLTSTLLDRRVSLWTRDKRLAAAAQKVGATVHASANSPH

Nucleotide

• Length: 384 bp

>T23526 NC_011989:c602606-602223 [Agrobacterium vitis S4]
GTGATCCTTGTCGATACATCAATCTGGATCGATCATTTTCGACATGGCGACGTAGAGCTATGCAAAATCATCGAGGATGA
TCGACTGCTCTGCCACCCTTTCGTTATCGGCGAACTGGCTCTCGGAAGCCTGAGAGAACGAGAGGCTGTCATAGGATTTT
TGGCAGCTCAACGCGAAGCAGCTATTGCGACCCATGCTGAAGTCATGACGGTCATTGATCGCTATTCCATATTCAGTATG
GGAATTGGTTACACTGATGCACACCTTCTGACTTCAACACTCCTTGACCGGCGCGTAAGCTTGTGGACGAGAGATAAACG
GTTAGCAGCCGCGGCTCAAAAGGTTGGTGCCACGGTTCATGCATCGGCGAACAGCCCTCACTAG

Antitoxin

Protein

• Length: 67 a.a.
• Molecular weight: 7201.27 Da
• Isoelectric Point: 10.7407

>AT23526 WP_015914924.1 NC_011989:c602803-602603 [Agrobacterium vitis S4]
MRSTINLDDNLMERAKSLTGTKETAALVRQALETLVRVESGKRLIALGGSMSDAEAAPRRRSEVTK

Nucleotide

• Length: 201 bp

>AT23526 NC_011989:c602803-602603 [Agrobacterium vitis S4]
ATGCGGTCTACCATTAATCTCGACGACAACCTAATGGAACGGGCCAAGTCACTGACGGGCACGAAGGAAACCGCTGCTCT
TGTTCGCCAAGCGCTGGAGACGCTGGTGCGAGTTGAATCTGGCAAGCGTCTTATCGCTCTTGGCGGATCCATGTCCGACG
CCGAGGCAGCCCCTCGCCGCCGGAGCGAAGTGACCAAGTGA

Structures

Toxin

• AlphaFold DB: B9JRM2

Antitoxin

• AlphaFold DB: B9JRM3