Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1776489..1777320 Replicon chromosome
Accession NZ_CP091925
Organism Escherichia coli strain JNQH497

Toxin (Protein)


Gene name yeeV Uniprot ID F4THW6
Locus tag KIF99_RS08385 Protein ID WP_000854818.1
Coordinates 1776489..1776863 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID F4THW5
Locus tag KIF99_RS08390 Protein ID WP_001313071.1
Coordinates 1776952..1777320 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KIF99_RS08350 (1772485) 1772485..1772814 + 330 WP_000450409.1 DUF496 family protein -
KIF99_RS08355 (1772915) 1772915..1773238 - 324 WP_223216378.1 EutP/PduV family microcompartment system protein -
KIF99_RS08360 (1773217) 1773217..1773297 + 81 WP_023441679.1 hypothetical protein -
KIF99_RS08365 (1773661) 1773661..1774407 - 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
KIF99_RS08370 (1774422) 1774422..1775963 - 1542 WP_001298859.1 IS21-like element ISEc12 family transposase -
KIF99_RS08375 (1776172) 1776172..1776252 - 81 Protein_1644 hypothetical protein -
KIF99_RS08380 (1776298) 1776298..1776492 - 195 WP_000988600.1 DUF5983 family protein -
KIF99_RS08385 (1776489) 1776489..1776863 - 375 WP_000854818.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
KIF99_RS08390 (1776952) 1776952..1777320 - 369 WP_001313071.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KIF99_RS08395 (1777400) 1777400..1777621 - 222 WP_000692301.1 DUF987 domain-containing protein -
KIF99_RS08400 (1777684) 1777684..1778160 - 477 WP_001186726.1 RadC family protein -
KIF99_RS08405 (1778176) 1778176..1778655 - 480 WP_000860076.1 antirestriction protein -
KIF99_RS08410 (1778737) 1778737..1779558 - 822 WP_001234530.1 DUF932 domain-containing protein -
KIF99_RS08415 (1779779) 1779779..1780189 - 411 WP_000846713.1 hypothetical protein -
KIF99_RS08420 (1780205) 1780205..1780888 - 684 WP_042004735.1 hypothetical protein -
KIF99_RS08425 (1781024) 1781024..1782094 - 1071 WP_000102643.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13972.98 Da        Isoelectric Point: 7.1333

>T235253 WP_000854818.1 NZ_CP091925:c1776863-1776489 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T235253 NZ_LR134231:c4125943-4125770 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13498.23 Da        Isoelectric Point: 5.8696

>AT235253 WP_001313071.1 NZ_CP091925:c1777320-1776952 [Escherichia coli]
VSDTLSGTTHPDDNNSHPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT235253 NZ_LR134231:c4126267-4125971 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3W3PHA3

Antitoxin

Source ID Structure
AlphaFold DB A0A1M1L2Z3

References