Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/DUF433(antitoxin)
Location 5815098..5815657 Replicon chromosome
Accession NZ_CP091913
Organism Nostoc sp. UHCC 0870

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L6494_RS24665 Protein ID WP_237990360.1
Coordinates 5815319..5815657 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L6494_RS24660 Protein ID WP_237990359.1
Coordinates 5815098..5815322 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6494_RS24655 (L6494_24660) 5811477..5815034 + 3558 WP_237990358.1 transcription-repair coupling factor -
L6494_RS24660 (L6494_24665) 5815098..5815322 + 225 WP_237990359.1 DUF433 domain-containing protein Antitoxin
L6494_RS24665 (L6494_24670) 5815319..5815657 + 339 WP_237990360.1 DUF5615 family PIN-like protein Toxin
L6494_RS24670 (L6494_24675) 5815673..5816236 + 564 WP_237990361.1 Uma2 family endonuclease -
L6494_RS24675 (L6494_24680) 5816246..5816504 + 259 Protein_4891 hypothetical protein -
L6494_RS24680 (L6494_24685) 5816692..5816907 + 216 WP_237990362.1 hypothetical protein -
L6494_RS24685 (L6494_24690) 5816908..5817327 + 420 WP_237990364.1 type II toxin-antitoxin system VapC family toxin -
L6494_RS24690 (L6494_24695) 5817601..5818083 + 483 WP_237990365.1 hypothetical protein -
L6494_RS24695 (L6494_24700) 5818170..5818448 - 279 WP_237990366.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Domain of unknown function DUF5615

(1-78)

Antitoxin

Protein of unknown function DUF433

(8-63)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12380.28 Da        Isoelectric Point: 4.2577

>T235246 WP_237990360.1 NZ_CP091913:5815319-5815657 [Nostoc sp. UHCC 0870]
MTIWIDAHLSPTIATWISNTFGITALALRDVGLRDAEDLEIFEVAKTQGVIFITKDSDFVDLVERLGTPPQIIWLTCGNT
SNSRLQEILIATLPKALELLRTGEKLVEISGE

Download         Length: 339 bp

>T235246 NZ_LR134231:c2350927-2350751 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8132.53 Da        Isoelectric Point: 6.9465

>AT235246 WP_237990359.1 NZ_CP091913:5815098-5815322 [Nostoc sp. UHCC 0870]
MSNLLSRITVNPKQCGGRPCIRGMRIRVSDVLDLFAAGLNAEQILEEMPDLEADDLKAALLYASRKLNHPVLVA

Download         Length: 225 bp

>AT235246 NZ_LR134231:c2350705-2350289 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References