Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 5174868..5175423 Replicon chromosome
Accession NZ_CP091913
Organism Nostoc sp. UHCC 0870

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag L6494_RS21870 Protein ID WP_237989856.1
Coordinates 5174868..5175212 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag L6494_RS21875 Protein ID WP_190708513.1
Coordinates 5175199..5175423 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6494_RS21855 (L6494_21860) 5170329..5172764 + 2436 WP_237989853.1 beta-propeller fold lactonase family protein -
L6494_RS21860 (L6494_21865) 5173112..5173753 - 642 WP_237989854.1 hypothetical protein -
L6494_RS21865 (L6494_21870) 5173878..5174798 - 921 WP_237989855.1 SGNH/GDSL hydrolase family protein -
L6494_RS21870 (L6494_21875) 5174868..5175212 - 345 WP_237989856.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
L6494_RS21875 (L6494_21880) 5175199..5175423 - 225 WP_190708513.1 CopG family transcriptional regulator Antitoxin
L6494_RS21880 (L6494_21885) 5175961..5178837 + 2877 WP_237989857.1 glycerol-3-phosphate acyltransferase -
L6494_RS21885 (L6494_21890) 5178834..5179184 + 351 WP_237989858.1 cupin domain-containing protein -
L6494_RS21890 (L6494_21895) 5179258..5180139 - 882 WP_237989859.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12765.69 Da        Isoelectric Point: 9.5606

>T235244 WP_237989856.1 NZ_CP091913:c5175212-5174868 [Nostoc sp. UHCC 0870]
MKRGDIYYANLSRTLGSEMDKRRPVLIVSNDANNRAASTVTILPLTSNVSRVYPFEVLLNPEDSGLPLASKVQAQQVRTI
SKQRIVSEVVNSLSEELMQLVDASLKLHLELEKR

Download         Length: 345 bp

>T235244 NZ_LR134231:2214082-2214369 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8453.50 Da        Isoelectric Point: 4.1948

>AT235244 WP_190708513.1 NZ_CP091913:c5175423-5175199 [Nostoc sp. UHCC 0870]
MQVEKLSISLPASLVQFIEGYKVAHECKSRSQVIEKALQLLRTQELEQAYREASAEVDNDWEITITDGLTDEAW

Download         Length: 225 bp

>AT235244 NZ_LR134231:2213843-2214082 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References