Detailed information of TA system TA235242

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 4676657..4677450
• Replicon: chromosome
• Accession: NZ_CP091913
• Organism: Nostoc sp. UHCC 0870

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: L6494_RS19710
• Protein ID: WP_237989442.1
• Coordinates: 4676935..4677450 (+)
• Length: 172 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: -
• Locus tag: L6494_RS19705
• Protein ID: WP_237989440.1
• Coordinates: 4676657..4676935 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L6494_RS19680 (L6494_19680)	4671924..4672883	+	960	WP_237989434.1	glycosyltransferase family 2 protein	-
L6494_RS19685 (L6494_19685)	4672919..4674007	+	1089	WP_237989435.1	dTDP-glucose 4,6-dehydratase	-
L6494_RS19690 (L6494_19690)	4674035..4674973	+	939	WP_237989436.1	glucose-1-phosphate thymidylyltransferase RfbA	-
L6494_RS19695 (L6494_19695)	4674999..4675544	+	546	WP_237989437.1	dTDP-4-dehydrorhamnose 3,5-epimerase	-
L6494_RS19700 (L6494_19700)	4675541..4676422	+	882	WP_237989438.1	dTDP-4-dehydrorhamnose reductase	-
L6494_RS19705 (L6494_19705)	4676657..4676935	+	279	WP_237989440.1	DUF1778 domain-containing protein	Antitoxin
L6494_RS19710 (L6494_19710)	4676935..4677450	+	516	WP_237989442.1	GNAT family N-acetyltransferase	Toxin
L6494_RS19715 (L6494_19715)	4677632..4678201	-	570	WP_237989443.1	thermonuclease family protein	-
L6494_RS19720 (L6494_19720)	4678325..4678687	+	363	WP_237989444.1	metalloregulator ArsR/SmtB family transcription factor	-
L6494_RS19725 (L6494_19725)	4678748..4679830	-	1083	WP_237989445.1	photosystem II q(b) protein	-
L6494_RS19730 (L6494_19730)	4680219..4681226	-	1008	WP_237989446.1	NAD(P)/FAD-dependent oxidoreductase	-
L6494_RS19735 (L6494_19735)	4681341..4681712	-	372	WP_237989447.1	rhodanese-like domain-containing protein	-
L6494_RS19740 (L6494_19740)	4681848..4682384	-	537	WP_237989449.1	cytochrome b6-f complex iron-sulfur subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (43-147)

Antitoxin

• Vibrio phage ICP1, Orf50 (3-91)

Sequences

Toxin

Protein

• Length: 172 a.a.
• Molecular weight: 19079.10 Da
• Isoelectric Point: 8.6601

>T235242 WP_237989442.1 NZ_CP091913:4676935-4677450 [Nostoc sp. UHCC 0870]
MSLDSLYIEKLSASQNIQDFDCGKPALNHFLINYALQNQQSDSSKTYVACVDNHVIGYYTLTVASVIHQDAPPRIIKGLP
KYPIPVALLARLAVSKDFQGKRIGSGLLKDCLKRVNAAADILGIRALLVHAKDNQARAWYENFDFEPSPTDPLHLFLMLK
DIRKMLASLHS

Nucleotide

• Length: 516 bp

>T235242 NZ_LR134231:1751311-1751565 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10414.66 Da
• Isoelectric Point: 6.7260

>AT235242 WP_237989440.1 NZ_CP091913:4676657-4676935 [Nostoc sp. UHCC 0870]
MSHSPESRTERIDIRTSPNVKKLLQQAAAASHKNVSEFLLEHGLTAAQDALTNRKVFALDDEQWQAFQNALDSPTTDKPR
LRRLLTEPSVFE

Nucleotide

• Length: 279 bp

>AT235242 NZ_LR134231:1751063-1751314 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA