Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3390696..3391302 Replicon chromosome
Accession NZ_CP091913
Organism Nostoc sp. UHCC 0870

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag L6494_RS14355 Protein ID WP_237988396.1
Coordinates 3391006..3391302 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag L6494_RS14350 Protein ID WP_237988395.1
Coordinates 3390696..3391016 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6494_RS14320 (L6494_14315) 3386546..3386884 + 339 WP_237988389.1 hypothetical protein -
L6494_RS14325 (L6494_14320) 3386912..3387160 + 249 WP_237988390.1 DUF4926 domain-containing protein -
L6494_RS14330 (L6494_14325) 3387299..3387754 - 456 WP_237988391.1 type II toxin-antitoxin system VapC family toxin -
L6494_RS14335 (L6494_14330) 3387687..3387950 - 264 WP_237988392.1 hypothetical protein -
L6494_RS14340 (L6494_14335) 3388093..3388863 - 771 WP_237988393.1 Ycf66 family protein -
L6494_RS14345 (L6494_14340) 3389087..3390517 + 1431 WP_237988394.1 NADP-dependent phosphogluconate dehydrogenase -
L6494_RS14350 (L6494_14345) 3390696..3391016 - 321 WP_237988395.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
L6494_RS14355 (L6494_14350) 3391006..3391302 - 297 WP_237988396.1 type II toxin-antitoxin system HicA family toxin Toxin
L6494_RS14360 (L6494_14355) 3391409..3392557 - 1149 WP_237988397.1 serine/threonine-protein kinase -
L6494_RS14365 (L6494_14360) 3392803..3393834 + 1032 WP_237988398.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-75)

Antitoxin

Uncharacterised protein family HicB

(51-101)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10949.31 Da        Isoelectric Point: 7.3215

>T235241 WP_237988396.1 NZ_CP091913:c3391302-3391006 [Nostoc sp. UHCC 0870]
MGLNSKHQKTLDDIFENPVRSNIPWSDIESMLIALGAEVSEGRGSRVRIALNSVKATFHRPHPEKETNKGAVKSMRRFLT
ESRVKEDTDTGGLSDNEI

Download         Length: 297 bp

>T235241 NZ_LR134231:1751063-1751314 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12301.04 Da        Isoelectric Point: 4.9799

>AT235241 WP_237988395.1 NZ_CP091913:c3391016-3390696 [Nostoc sp. UHCC 0870]
MKYKGYEAVVEFDDEAEIFHGEVVNLRDVITFQGDSVKELRQAFHDSVDDYLEFCQKRGEEPEKPFSGKLMLRINPELHK
TIAIKAKKEGQSLNSWIEKCLCMYAP

Download         Length: 321 bp

>AT235241 NZ_LR134231:1751311-1751565 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References