Detailed information of TA system TA023524

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapB(antitoxin)
• Location: 3595406..3595958
• Replicon: chromosome
• Accession: NC_011979
• Organism: Geobacter daltonii FRC-32

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: B9M4S9
• Locus tag: GEOB_RS16240
• Protein ID: WP_012648341.1
• Coordinates: 3595605..3595958 (+)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: B9M4S8
• Locus tag: GEOB_RS16235
• Protein ID: WP_012648340.1
• Coordinates: 3595406..3595618 (+)
• Length: 71 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GEOB_RS16210	3590424..3591359	+	936	WP_012648335.1	aspartate carbamoyltransferase catalytic subunit	-
GEOB_RS16215	3591477..3592754	+	1278	WP_012648336.1	dihydroorotase	-
GEOB_RS16220	3592845..3593966	+	1122	WP_012648337.1	glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit	-
GEOB_RS16225	3594049..3594975	+	927	WP_012648338.1	radical SAM protein	-
GEOB_RS16230	3594972..3595301	+	330	WP_012648339.1	DMT family protein	-
GEOB_RS16235	3595406..3595618	+	213	WP_012648340.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
GEOB_RS16240	3595605..3595958	+	354	WP_012648341.1	type II toxin-antitoxin system VapC family toxin	Toxin
GEOB_RS16245	3596011..3599253	+	3243	WP_012648342.1	carbamoyl-phosphate synthase large subunit	-
GEOB_RS16250	3599337..3599813	+	477	WP_012648343.1	transcription elongation factor GreA	-
GEOB_RS16255	3599855..3600052	+	198	WP_012648344.1	DUF1858 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-42)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13225.48 Da
• Isoelectric Point: 5.8796

>T23524 WP_012648341.1 NC_011979:3595605-3595958 [Geobacter daltonii FRC-32]
MILVDTSVWVEHFRSGAVGLETFLNDGQVICHPFIIGELACGNLKNRTQILSLLQDLPKAFCADDDEVIRFIDDHKLMGK
GLGYIDIHLLMSALLTQVPLWTMDKRLHEVSLSLLRH

Nucleotide

• Length: 354 bp

>T23524 NC_011979:3595605-3595958 [Geobacter daltonii FRC-32]
ATGATCCTTGTTGATACATCTGTCTGGGTGGAGCATTTCCGCTCAGGCGCAGTCGGCCTTGAAACATTTCTGAATGACGG
TCAGGTCATCTGCCACCCCTTCATTATCGGTGAGCTGGCATGTGGGAATCTGAAGAACAGGACACAGATTCTTTCCCTTC
TTCAGGACCTCCCCAAGGCTTTTTGTGCCGACGATGACGAGGTGATCCGGTTCATCGACGACCATAAACTGATGGGTAAG
GGCCTTGGCTACATCGATATCCATCTGCTAATGTCCGCCTTGCTCACACAGGTGCCCCTCTGGACCATGGACAAAAGGCT
GCATGAGGTTTCGCTGTCGCTACTGCGCCACTGA

Antitoxin

Protein

• Length: 71 a.a.
• Molecular weight: 7616.03 Da
• Isoelectric Point: 10.6866

>AT23524 WP_012648340.1 NC_011979:3595406-3595618 [Geobacter daltonii FRC-32]
MRTTLNIEDALLEKAVKLTGITEKTSLVKLGLQALIAKESARRLAGLAGSEKGLKMPPRRRVKAKDDDPC

Nucleotide

• Length: 213 bp

>AT23524 NC_011979:3595406-3595618 [Geobacter daltonii FRC-32]
ATGAGAACAACGCTCAATATCGAAGATGCCCTGTTGGAAAAGGCGGTAAAGCTGACCGGCATAACGGAAAAAACTTCCCT
TGTAAAACTTGGGTTACAGGCGCTGATCGCCAAGGAGAGCGCCAGAAGGCTGGCAGGTCTGGCAGGGAGTGAAAAAGGCC
TGAAAATGCCCCCGCGGAGAAGGGTAAAGGCTAAAGACGATGATCCTTGTTGA

Structures

Toxin

• AlphaFold DB: B9M4S9

Antitoxin

• AlphaFold DB: B9M4S8