Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 2097436..2098065 Replicon chromosome
Accession NZ_CP091913
Organism Nostoc sp. UHCC 0870

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L6494_RS09075 Protein ID WP_237993989.1
Coordinates 2097664..2098065 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L6494_RS09070 Protein ID WP_237993987.1
Coordinates 2097436..2097663 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6494_RS09040 (L6494_09035) 2093949..2094260 - 312 WP_190699577.1 hypothetical protein -
L6494_RS09045 (L6494_09040) 2094478..2094633 - 156 WP_237996324.1 hypothetical protein -
L6494_RS09050 (L6494_09045) 2094921..2095139 - 219 WP_237993972.1 hypothetical protein -
L6494_RS09055 (L6494_09050) 2095329..2096120 - 792 WP_237993980.1 Nif3-like dinuclear metal center hexameric protein -
L6494_RS09060 (L6494_09055) 2096120..2096869 - 750 WP_237993983.1 hypothetical protein -
L6494_RS09065 (L6494_09060) 2097041..2097307 - 267 WP_237993985.1 hypothetical protein -
L6494_RS09070 (L6494_09065) 2097436..2097663 + 228 WP_237993987.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
L6494_RS09075 (L6494_09070) 2097664..2098065 + 402 WP_237993989.1 type II toxin-antitoxin system VapC family toxin Toxin
L6494_RS09080 (L6494_09075) 2098298..2098711 - 414 WP_237993992.1 secondary thiamine-phosphate synthase enzyme YjbQ -
L6494_RS09085 (L6494_09080) 2098769..2099857 - 1089 WP_237993994.1 glycosyl transferase -
L6494_RS09090 (L6494_09085) 2100008..2101252 - 1245 WP_237993996.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14891.31 Da        Isoelectric Point: 6.4614

>T235239 WP_237993989.1 NZ_CP091913:2097664-2098065 [Nostoc sp. UHCC 0870]
MRYLLDTNICIYLIKHKPQKVLDKFQTLSLSDVGISSITVAELEYGVAKSQQQNKNRTALLQFLLPLEIVEFNQASATIY
GSIRSDLESRGLIIGAMDLLIAAHTLSLGVTLVTNNTREFARIPTLLLENWVE

Download         Length: 402 bp

>T235239 NZ_LR134231:830028-830435 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.58 Da        Isoelectric Point: 4.0780

>AT235239 WP_237993987.1 NZ_CP091913:2097436-2097663 [Nostoc sp. UHCC 0870]
MNIAKLSTDGTHQFVILPEDFQLTGTEVYIKKIGNAIVLIAKDNPWESLIESLDNFSDDFMTTRDQPPIDTRESL

Download         Length: 228 bp

>AT235239 NZ_LR134231:829781-830047 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References