Detailed information of TA system TA235238

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataRT/DUF1778(antitoxin)
• Location: 878305..879119
• Replicon: chromosome
• Accession: NZ_CP091913
• Organism: Nostoc sp. UHCC 0870

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: -
• Locus tag: L6494_RS03755
• Protein ID: WP_237991517.1
• Coordinates: 878305..878814 (-)
• Length: 170 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: -
• Locus tag: L6494_RS03760
• Protein ID: WP_237991518.1
• Coordinates: 878814..879119 (-)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L6494_RS03730 (L6494_03730)	873745..874203	+	459	WP_237991512.1	ribosome silencing factor	-
L6494_RS03735 (L6494_03735)	874200..874700	+	501	WP_237991513.1	CGLD27 family protein	-
L6494_RS03740 (L6494_03740)	874777..875730	+	954	WP_237991514.1	asparaginase	-
L6494_RS03745 (L6494_03745)	876177..876656	+	480	WP_237991515.1	group I intron-associated PD-(D/E)XK endonuclease	-
L6494_RS03750 (L6494_03750)	876698..878125	+	1428	WP_237991516.1	DUF697 domain-containing protein	-
L6494_RS03755 (L6494_03755)	878305..878814	-	510	WP_237991517.1	GNAT family N-acetyltransferase	Toxin
L6494_RS03760 (L6494_03760)	878814..879119	-	306	WP_237991518.1	DUF1778 domain-containing protein	Antitoxin
L6494_RS03765 (L6494_03765)	879241..879903	-	663	WP_237991519.1	Na(+)/H(+) antiporter subunit B	-
L6494_RS03770 (L6494_03770)	879900..880484	-	585	WP_237991520.1	DUF4040 domain-containing protein	-
L6494_RS03775 (L6494_03775)	880477..880755	-	279	WP_237991521.1	monovalent cation/H(+) antiporter subunit G	-
L6494_RS03780 (L6494_03780)	880752..881009	-	258	WP_237991522.1	hypothetical protein	-
L6494_RS03785 (L6494_03785)	881006..881392	-	387	WP_237991523.1	Na+/H+ antiporter subunit E	-
L6494_RS03790 (L6494_03790)	881389..882822	-	1434	WP_237991524.1	cation:proton antiporter	-
L6494_RS03795 (L6494_03795)	882819..883154	-	336	WP_237991525.1	cation:proton antiporter subunit C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (46-147)

Antitoxin

• Vibrio phage ICP1, Orf50 (21-95)

Sequences

Toxin

Protein

• Length: 170 a.a.
• Molecular weight: 18954.18 Da
• Isoelectric Point: 9.8607

>T235238 WP_237991517.1 NZ_CP091913:c878814-878305 [Nostoc sp. UHCC 0870]
MIKQTKTINPPQLITNEHNVLDFNSKSEALNQWLKEKALKNEGDTARTYVVTIKNQVIGYYCLATSSVAHVIATSKAKRN
APDPIPCMLIGRLAVDIKWEGRGIGSGLLRDAIFRILKVTEIVGIRCILVHAKDEEAKNFYLKHRFQASPIEPLTLMITI
KDIQASLKD

Nucleotide

• Length: 510 bp

>T235238 NZ_LR134231:645725-646039 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11706.25 Da
• Isoelectric Point: 4.5641

>AT235238 WP_237991518.1 NZ_CP091913:c879119-878814 [Nostoc sp. UHCC 0870]
MDRETMVSRSKMDNLGRNQVINIRVQEQQRDLIDYAASILGKSRSDFMLEVACREAENVICGNTFFALDEEKYQEFLAIL
DSPPQADKELRKFLSTKSPWD

Nucleotide

• Length: 306 bp

>AT235238 NZ_LR134231:646036-646452 [Escherichia coli]
ATGATTGCGATTGCCGATATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA