Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 2457059..2457687 Replicon chromosome
Accession NC_011979
Organism Geobacter daltonii FRC-32

Toxin (Protein)


Gene name vapC Uniprot ID B9M9K0
Locus tag GEOB_RS11035 Protein ID WP_012647301.1
Coordinates 2457059..2457460 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B9M9K1
Locus tag GEOB_RS11040 Protein ID WP_012647302.1
Coordinates 2457460..2457687 (-) Length 76 a.a.

Genomic Context

GEOB_RS11000GEOB_RS11005GEOB_RS11010GEOB_RS11015GEOB_RS11020GEOB_RS11025GEOB_RS11030GEOB_RS11050GEOB_RS11055GEOB_RS11060GEOB_RS11035GEOB_RS11040GEOB_RS11045
Location: 2452287..2452649 (363 bp)
Type: Others
Protein ID: WP_012647293.1
Location: 2452646..2453365 (720 bp)
Type: Others
Protein ID: WP_012647294.1
Location: 2453402..2453911 (510 bp)
Type: Others
Protein ID: WP_012647295.1
Location: 2453988..2454329 (342 bp)
Type: Others
Protein ID: WP_012647296.1
Location: 2454392..2455435 (1044 bp)
Type: Others
Protein ID: WP_012647297.1
Location: 2455656..2456336 (681 bp)
Type: Others
Protein ID: WP_012647298.1
Location: 2456461..2457012 (552 bp)
Type: Others
Protein ID: WP_012647300.1
Location: 2458580..2459239 (660 bp)
Type: Others
Protein ID: WP_012647304.1
Location: 2459285..2459983 (699 bp)
Type: Others
Protein ID: WP_012647305.1
Location: 2459992..2461296 (1305 bp)
Type: Others
Protein ID: WP_154650565.1
Location: 2457059..2457460 (402 bp)
Type: Toxin
Protein ID: WP_012647301.1
Location: 2457460..2457687 (228 bp)
Type: Antitoxin
Protein ID: WP_012647302.1
Location: 2457817..2458188 (372 bp)
Type: Others
Protein ID: WP_012647303.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GEOB_RS110002452287..2452649+363WP_012647293.1CidA/LrgA family protein-
GEOB_RS110052452646..2453365+720WP_012647294.1LrgB family protein-
GEOB_RS110102453402..2453911+510WP_012647295.1shikimate kinase-
GEOB_RS110152453988..2454329+342WP_012647296.1metalloregulator ArsR/SmtB family transcription factor-
GEOB_RS110202454392..2455435+1044WP_012647297.1ACR3 family arsenite efflux transporter-
GEOB_RS110252455656..2456336+681WP_012647298.1DUF2461 domain-containing protein-
GEOB_RS110302456461..2457012+552WP_012647300.1hypothetical protein-
GEOB_RS110352457059..2457460-402WP_012647301.1type II toxin-antitoxin system VapC family toxinToxin
GEOB_RS110402457460..2457687-228WP_012647302.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
GEOB_RS110452457817..2458188-372WP_012647303.1pyridoxamine 5'-phosphate oxidase family protein-
GEOB_RS110502458580..2459239+660WP_012647304.1hypothetical protein-
GEOB_RS110552459285..2459983+699WP_012647305.1hypothetical protein-
GEOB_RS110602459992..2461296+1305WP_154650565.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14724.07 Da        Isoelectric Point: 5.1546

>T23521 WP_012647301.1 NC_011979:c2457460-2457059 [Geobacter daltonii FRC-32]
MKLLLDTNICIYIIKQQPDTVLKHFLEYEIGDIGISSITLSELRYGVAKSAHREKNAKALDEFIIPLEVVAYDEAAAHVY
GDIRSTLEKAGSPIGSMDMLIAAHAVSLGIPLVTNNTREFLRVPSINLLDWTV

Download         Length: 402 bp

>T23521 NC_011979:c2457460-2457059 [Geobacter daltonii FRC-32]
ATGAAACTGCTGCTCGACACCAATATCTGTATTTATATCATCAAGCAACAGCCGGACACCGTGTTGAAGCATTTTCTGGA
GTACGAGATCGGTGACATTGGCATTTCCTCCATAACCCTCTCCGAACTGCGCTACGGGGTCGCAAAAAGCGCTCACCGAG
AAAAAAACGCCAAAGCTCTCGACGAGTTCATCATCCCCCTGGAGGTGGTCGCTTATGATGAAGCGGCTGCCCACGTTTAT
GGAGATATCAGATCGACTCTTGAAAAAGCCGGCTCCCCCATTGGTTCCATGGATATGCTCATTGCCGCTCACGCCGTATC
ATTGGGAATCCCTCTGGTTACAAATAACACCCGCGAGTTTTTGCGCGTCCCCTCCATCAACCTTCTTGATTGGACAGTTT
GA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8806.00 Da        Isoelectric Point: 9.1844

>AT23521 WP_012647302.1 NC_011979:c2457687-2457460 [Geobacter daltonii FRC-32]
MKTAKIFQNGQSQAVRLPKEFRFDDSEVFIKKCGNIVQLIPRSDSWDSLFGSLKKFSSDFMSERIQPEQDKRENF

Download         Length: 228 bp

>AT23521 NC_011979:c2457687-2457460 [Geobacter daltonii FRC-32]
ATGAAAACAGCAAAAATATTTCAAAATGGACAAAGCCAGGCAGTCAGGCTCCCTAAGGAATTTCGCTTCGATGACAGCGA
GGTATTCATAAAGAAATGCGGCAACATCGTCCAATTGATCCCCCGGAGCGATTCGTGGGATTCTTTATTCGGCAGTCTCA
AAAAATTCTCAAGCGACTTCATGTCTGAACGCATACAACCTGAACAGGACAAGCGGGAAAATTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBB9M9K0

Antitoxin

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Source
ID
Structure
AlphaFold DBB9M9K1

References