Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ImmA-IrrE/HTH_19(antitoxin) |
| Location | 468797..469482 | Replicon | chromosome |
| Accession | NZ_CP091904 | ||
| Organism | Enterococcus faecalis strain 43-2 | ||
Toxin (Protein)
| Gene name | IrrE | Uniprot ID | R3GRW3 |
| Locus tag | L5I20_RS02455 | Protein ID | WP_010826722.1 |
| Coordinates | 468797..469141 (-) | Length | 115 a.a. |
Antitoxin (Protein)
| Gene name | ImmA | Uniprot ID | - |
| Locus tag | L5I20_RS02460 | Protein ID | WP_010826721.1 |
| Coordinates | 469159..469482 (-) | Length | 108 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L5I20_RS02415 (463860) | 463860..464693 | + | 834 | WP_104875383.1 | N-acetylmuramoyl-L-alanine amidase | - |
| L5I20_RS02425 (464949) | 464949..465185 | + | 237 | WP_002373089.1 | hypothetical protein | - |
| L5I20_RS02430 (465177) | 465177..466019 | - | 843 | WP_102970096.1 | toll/interleukin-1 receptor domain-containing protein | - |
| L5I20_RS02435 (466113) | 466113..466361 | - | 249 | WP_104875384.1 | hypothetical protein | - |
| L5I20_RS02440 (466461) | 466461..466550 | + | 90 | Protein_458 | JAB domain-containing protein | - |
| L5I20_RS02445 (466572) | 466572..467939 | - | 1368 | WP_048960569.1 | recombinase family protein | - |
| L5I20_RS02450 (468034) | 468034..468762 | - | 729 | WP_010826723.1 | potassium channel family protein | - |
| L5I20_RS02455 (468797) | 468797..469141 | - | 345 | WP_010826722.1 | ImmA/IrrE family metallo-endopeptidase | Toxin |
| L5I20_RS02460 (469159) | 469159..469482 | - | 324 | WP_010826721.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| L5I20_RS02465 (469790) | 469790..469972 | + | 183 | WP_010731660.1 | hypothetical protein | - |
| L5I20_RS02470 (469969) | 469969..470178 | - | 210 | WP_010731659.1 | hypothetical protein | - |
| L5I20_RS02475 (470374) | 470374..470796 | - | 423 | WP_010828994.1 | hypothetical protein | - |
| L5I20_RS02480 (470875) | 470875..471051 | + | 177 | WP_002364354.1 | helix-turn-helix transcriptional regulator | - |
| L5I20_RS02485 (471062) | 471062..471205 | + | 144 | WP_162837301.1 | hypothetical protein | - |
| L5I20_RS02490 (471399) | 471399..471869 | + | 471 | WP_048960565.1 | hypothetical protein | - |
| L5I20_RS02495 (471957) | 471957..472277 | + | 321 | WP_048960563.1 | hypothetical protein | - |
| L5I20_RS02500 (472277) | 472277..472501 | + | 225 | WP_002367281.1 | hypothetical protein | - |
| L5I20_RS02505 (472602) | 472602..473567 | + | 966 | WP_048960559.1 | RecT family recombinase | - |
| L5I20_RS02510 (473530) | 473530..474345 | + | 816 | WP_048960558.1 | PD-(D/E)XK nuclease-like domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 375727..519989 | 144262 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 115 a.a. Molecular weight: 13705.65 Da Isoelectric Point: 6.1363
>T235191 WP_010826722.1 NZ_CP091904:c469141-468797 [Enterococcus faecalis]
MKSIKELVEEYEVELVFAPINKRACYESVKRIIFVNQNLSIEEQEEAIFHEFKHVVSHSDYMELYKIPSFRNKMEAEADH
HMFKCLIEKHDGQFNYSNVITHYNLKMGQENYLK
MKSIKELVEEYEVELVFAPINKRACYESVKRIIFVNQNLSIEEQEEAIFHEFKHVVSHSDYMELYKIPSFRNKMEAEADH
HMFKCLIEKHDGQFNYSNVITHYNLKMGQENYLK
Download Length: 345 bp
>T235191 NZ_LR134227:c600143-599679 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA
Antitoxin
Download Length: 108 a.a. Molecular weight: 12330.96 Da Isoelectric Point: 5.2520
>AT235191 WP_010826721.1 NZ_CP091904:c469482-469159 [Enterococcus faecalis]
MTVFDRVKKLADSQKISIVELEEKLNFSRNSLYAWKKSKPSIDKLEAVANYFGVSTDYLLGREISNKPKQSDDLDEILDN
VMSFDGEPLDDHDREVIRAYLKGRFGK
MTVFDRVKKLADSQKISIVELEEKLNFSRNSLYAWKKSKPSIDKLEAVANYFGVSTDYLLGREISNKPKQSDDLDEILDN
VMSFDGEPLDDHDREVIRAYLKGRFGK
Download Length: 324 bp
>AT235191 NZ_LR134227:c600478-600143 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|